PlGF及其受体Flt-1在胃癌组织中的表达及临床意义  

Expression of placental growth factor and vascular endothelial growth factor receptor-1 in gastric cancer and the clinical significance

作　　者：绳继健[1] 何庆泗[1] 孙国瑞[1] 曲辉[1] 孔东方[1] 徐阳[1] 

机构地区：[1]山东大学齐鲁医院普外科,山东济南250012

出　　处：《中国现代普通外科进展》2012年第5期337-342,共6页Chinese Journal of Current Advances in General Surgery

基　　金：山东省优秀中青年科学家科研奖励基金(2008BS03059)

摘　　要：目的:探讨胎盘生长因子(PlGF)及其受体血管内皮生长因子受体-1(Flt-1)与胃癌血管形成和临床病理特点的关系。方法:应用免疫组织化学染色法检测84例胃癌组织及20例正常胃组织中的PlGF和Flt-1,并计算以CD34为标志的微血管密度(MVD),分析其与胃癌临床病理因素及预后的关系。结果:PlGF和Flt-1在胃癌组织中的表达均高于正常胃组织(P<0.05)。PlGF表达与胃癌的组织学分化程度、浸润深度、Borrmann分型、淋巴结转移有关(P<0.05);Flt-1表达与胃癌的浸润深度、Borrmann分型有关(P<0.05);MVD与肿瘤浸润深度、Borrmann分型、淋巴结转移有关(P<0.05)。PlGF与Flt-1表达阳性患者的5年存活率分别为45.5%、40.4%。浸润深度、Flt-1阳性表达为影响胃癌患者生存的独立预后因素。结论:PlGF/Flt-1通路可能在胃肿瘤血管发生及发展过程中起重要作用,从而影响胃癌的进展及预后。Objective： To explore the expression of protein PIGF with its receptor Fit-1 in gas- tric carcinoma and their relations with clinicopathological character and prognosis. Methods： A series of 84 human gastric adenocarcinoma cases that had undergone surgical resection was examined immunohistochemically using antibodies against PIGF, F;t-1 and CD34, followed by counting Mi-crovessel density. Results： PIGF positive staining was obtained in 66 out of 84 cases （78.6%）. F;t-1 positive staining was obtained in 57 out of 84 cases（67.9%）.Qver-expressed of PIGF was as- sociated with differentiation, invasion depth, Borrmann type, lymph node metastasis, Fit-1 was as- sociated with invasion depth, Borrmann type, MVD was associated with invasion depth, Borrmann type, lymph node metastasis. The 5-year survival rates which PIGF and Fit-1 was expressed were 45.5% and 40.4%. In multivariate analysis, the invasion depth and FIt-t expression were the inde- pendent hazard. Conclusion： The expressions of PIGF and Fit-1 are correlated with tumor angio- genesis, and they play an important role in new blood vessels formation. The expression of PIGF and Fit-1 were closely correlated with the tumor angiogenesis, tumor invasion and patient survival and may be prognostic indicator for human gastric cancer.

关 键 词：胃肿瘤 胎盘生长因子 血管内皮生长因子受体-1 微血管密度 

分 类 号：R735.2[医药卫生—肿瘤]