ATM与肿瘤的关系研究进展  

The research progress of the relevance of ATM with tumors

作　　者：刘小群[1] 乔田奎[1] 

机构地区：[1]复旦大学附属金山医院肿瘤科,上海200540

出　　处：《中国癌症杂志》2011年第12期973-977,共5页China Oncology

摘　　要：共济失调毛细血管扩张征突变基因(ataxia-telangiectasia mutated gene,ATM gene)属于一种DNA修复基因,定位于染色体11q22-q23。ATM基因的胚系突变或基因多态性导致个体对多种肿瘤易感,包括淋巴样肿瘤和实体瘤。ATM基因编码产物——ATM蛋白属于一种自动磷酸化蛋白激酶,在DNA损伤修复、细胞周期阻滞和细胞凋亡过程中发挥着关键的调控作用。体外实验发现,许多肿瘤的发生和治疗过程涉及了ATM蛋白表达或活性的改变,提示ATM基因或许能成为肿瘤治疗过程中一个新的潜在作用靶点。Ataxia-telangiectasia mutated gene（ATM gene）,being a kind of DNA-repair gene,is mapped to the chromosomal region 11q22-23.The ATM genetic germline mutation or polymorphism results in individual susceptibility to some tumors,including lymphoid tumors and solid tumors.The ATM protein encoded by the ATM gene possesses a kind of autophosphorating character allowing it to play a critical role in the signal transduction of cell cycle checkpoint and the repair of DNA damage and the apoptosis.In vitro,the expression of the ATM protein or the abnormality of its activation is implicated in oncogenesis and oncotherapy,thus the ATM gene would be a novel potential target in cancer treatment.

关 键 词：共济失调毛细血管扩张征突变基因 肿瘤 DNA损伤 细胞周期 凋亡 

分 类 号：R730.2[医药卫生—肿瘤]