Plasma levels of acylated ghrelin in patients with functional dyspepsia  

作　　者：Yeon Soo Kim Joon Seong Lee Tae Hee Lee Joo Young Cho Jin Oh Kim Wan Jung Kim Hyun Gun Kim Seong Ran Jeon Hoe Su Jeong 

机构地区：[1]Department of Internal Medicine,Hallym University College of Medicine,Chuncheon Sacred Heart Hospital,Gangwon-do 200-704,South Korea [2]Department of Internal Medicine,Soonchunhyang University College of Medicine,Soonchunhyang University Hospital,Seoul 140-743,South Korea [3]Department of Anatomy and Cell Biology,Hanyang University College of Medicine,222 Wangsimni-ro,Seongdong-gu,Seoul 133-792,South Korea

出　　处：《World Journal of Gastroenterology》2012年第18期2231-2237,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional dyspepsia.METHODS:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the study.The functional dyspepsia patients were each diagnosed based on the Rome Ⅲ criteria.Eligible patients completed a questionnaire concerning the severity of 10 symptoms.Plasma acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 kcal.RESULTS:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional dyspepsia.However,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain(r =-0.427,P = 0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety(r = 0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria(%)(r =-0.522,P = 0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the meal.CONCLUSION:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia.AIM：To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional dyspepsia.METHODS：Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the study.The functional dyspepsia patients were each diagnosed based on the Rome Ⅲ criteria.Eligible patients completed a questionnaire concerning the severity of 10 symptoms.Plasma acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 kcal.RESULTS：There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional dyspepsia.However,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain（r =-0.427,P = 0.047） and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety（r = 0.428,P =0.047）.Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria（%）（r =-0.522,P = 0.013）.Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the meal.CONCLUSION：Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia.

关 键 词：Functional dyspepsia Acylated ghrelin Electrogastrogram Rome Ⅲ criteria Dyspeptic symptoms 

分 类 号：R57[医药卫生—消化系统]