重组乙型肝炎疫苗(酿酒酵母)免疫新生儿13年后的效果观察  

The 13-year-lasting efficacy of yeast-derived hepatitis B vaccines among the newborns

作　　者：姚晴青[1] 董晓莲[2] 王学才[2] 王法弟[2] 徐海涛[2] 王晓丽[2] 陈胜玉[2] 范建良[2] 郑英杰[1] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室-公共卫生安全教育部重点实验室,上海200032 [2]浙江省德清县疾病预防控制中心,浙江湖州313200

出　　处：《复旦学报（医学版）》2012年第3期238-242,252,共6页Fudan University Journal of Medical Sciences

基　　金：浙江省医药卫生科学研究基金计划(A类)(2009A203);国家重大传染病防治科技重大专项(2008ZX10002-012)~~

摘　　要：目的对重组乙肝疫苗的长期有效性进行研究。方法乙肝母亲(35例)和健康母亲(100例)所生的新生儿按照0-1-6月的程序于1996年10月至1997年5月进行重组乙肝疫苗(酿酒酵母)免疫接种,免疫后13年(2010年)随访并进行乙肝相关血清学指标的检测和定量分析。结果成功随访到101例少年。3.96%(4/101)的少年出现天然的乙肝病毒感染(即HBcAb阳性),其母亲均为具高感染性的乙肝感染者,其中1例同时为乙肝携带者。婴儿乙肝疫苗免疫13年后其anti-HBs阳性率为82.2%(83/101),其中起始疫苗应答者中anti-HBs阳性率为83.5%(76/91)。乙肝感染母亲和健康母亲所生少年anti-HBs阳性率无统计学差异,但母亲乙肝感染所生的少年anti-HBs水平较高。结论重组乙肝疫苗(酿酒酵母)免疫后13年仍具有保护性,母亲乙肝感染长期影响着其子女处于较高的anti-HBs水平。Objective Long-term efficacy of recombinant hepatitis B vaccines was evaluated.Methods During 1996 to 1997,newborns whose mothers were either infected with（35 cases） or without（100 cases） hepatitis B virus（HBV） routinely received a 0-1-6 month formula of yeast-derived hepatitis B vaccines since birth.Their serological markers to HBV were re-assessed at the age of around 13 years.Results Finally 101 adolescents were followed up sucessfully,and 3.96%（4/101）of them exhibited a natural infection of HBV（hepatitis B core antibody,HBcAb positive）.All the 4 cases were born of the mother with high HBV infectivity,and one even was HBsAg-positive.Proportion of anti-HBs-positive adolescents was overall 82.2%（83/101） at the 13th year after vaccination,and 83.5%（76/91） among those initial vaccine responders.Mothers＇ HBV infection did not modify the proportion of anti-HBs-positive adolescents,but it could increase their anti-HBs levels in the long run.Conclusions The efficacy of yeast-derived hepatitis B vaccine could sustain for at least 13 years,and mothers＇ HBV infection would affect their children with long-term higher anti-HBs levels.

关 键 词：乙型肝炎疫苗 基因工程 有效性 乙型肝炎抗体 

分 类 号：R186.3[医药卫生—流行病学]