p53基因第72位密码子多态性与HPV相关食管鳞癌遗传易感性的研究  

The Correlation between p53 Codon 72 Polymorphism and the Risk of ESCC

作　　者：杨文君[1,2,3] 陈志强[4] 梁寒梅[1] 齐奇[1] 王银[2] 贾伟[4] 赵巍[2] 王立东[5] 叶晓锋[4] 吕怀盛[4] 

机构地区：[1]宁夏医科大学基础学院生物技术系,银川750004 [2]宁夏医科大学科技中心,银川750004 [3]宁夏医科大学生育力保持重点实验室,银川750004 [4]宁夏医科大学总医院,银川750004 [5]河南省郑州大学食管癌重点实验室,郑州452470

出　　处：《宁夏医科大学学报》2012年第5期444-447,452,F0003,共6页Journal of Ningxia Medical University

基　　金：国家自然科学基金(30860320;81160249;81160252;30960108);宁夏自然科学基金(NZ0880)

摘　　要：目的探究p53基因第72位密码子(codon72)多态性与HPV相关食管鳞癌的关联性。方法选择435例食管鳞癌(Esophageal Squamous Cell Carcinoma,ESCC)患者和550例健康对照,进行p53 codon72与食管鳞癌发生的关联研究。结果病例组的Arg/Arg基因型的频率高于对照组(85.7%vs 49.6%);Arg/Arg基因型携带者发生食管鳞癌的风险是携带Arg/Pro或Pro/Pro基因型个体的6.48倍(P<0.001)。结论 p53 co-don72纯合子Arg/Arg可能是HPV相关食管鳞癌发生的危险因素。Objective To address a potential correlation between the genotypes of p53 codon 72 and the risk of HPV related esophageal squamous cell carcinoma （ESCC）. Methods p53 codon 72 polymorphism in 435 patients with ESCC and 550 cancer -free subjects from the same geographical region were investigated. Results p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects （ 85.7 % vs 49.6%, P 〈 0.001 ）, resulting in an elevated ESCC risk （ OR = 6.48,95 %, CI = 4.65 - 9.03 ）. Conclusion p53 Arg represents a potential risk for the development of HPV related ESCC.

关 键 词：食管鳞癌 P53 多态性 

分 类 号：R735.1[医药卫生—肿瘤]