舍雷肽酶对预防复杂下颌阻生智齿拔除术后并发症的疗效观察  

Effect of serrapeptase on postoperative complication of mandibular complicated third molar extraction

作　　者：刘奕[1] 林松杉[1] 章禾[1] 周明[1] 杨瑞华[1] 

机构地区：[1]海军总医院口腔科,主治医师北京100048

出　　处：《口腔颌面修复学杂志》2012年第1期49-51,共3页Chinese Journal of Prosthodontics

摘　　要：目的:观察应用舍雷肽酶预防下颌复杂阻生智齿拔除术后并发症的疗效。方法:选取临床需拔除复杂下颌阻生智齿的患者60例,随机分为实验组和对照组,各30例。实验组术后给予舍雷肽酶肠溶片10mg,tid,7d和甲硝唑片0.2,tid,3d,阿莫西林胶囊0.5,tid,3d。对照组仅给予甲硝唑片0.2,tid,3d,阿莫西林胶囊0.5,tid,3d作为预防性抗感染治疗。观察两组术后第1、2、7d的局部肿胀,疼痛及张口受限情况,并作统计学分析。结果:术后第2天实验组的局部肿胀程度为(9.17±4.17)mm,明显低于对照组(13.97±6.10)mm,差异有统计学意义(P<0.01);实验组的疼痛评分2.32±0.98与对照组3.50±1.26相比差异有统计学意义(P<0.01)。张口受限情况两组间差异无统计学意义(P>0.05)。结论:舍雷肽酶对于减轻下颌阻生智齿拔除术后疼痛与肿胀反应具有明显疗效。Objective： To investigate the ability of serrapeptase to reduce postoperative swelling, pain and trismus after mandibular complicated wisdom teeth extraction. Methods： Sixty patients underwent impacted mandibular third molar extraction were involved and randomly divided into the treatment group which was given serrapeptase 10mg, tid, 7d and the control group which was given no serrapeptase. All the patients were given amoxicillin 0.5, tid, 3d and metronidazole 0.2, tid, 3d to prevent infection. The extent of check swelling, pain and interincisal distance were observed and measured on the 1 st, 2nd and 7th postoperative days. Results： On the 2nd day after the tooth extraction, the value of swelling in treatment group（9.17± 4.17）ram was obviously lower than that of control group （13.97± 6.10） ram, with statistically significant difference （P〈 0.01）. The pain score in the serrapeptase group was 2.32± 0.98, which showed significant difference （P〈 0.01） with the pain score of 3.50± 1.26 in the control group. However, there was no statistical significant difference between the two groups in trismus （P〉0.05）. Conclusion： The use of serrapeptase was effective to depress the postoperative negative re- actions of the mandibular complicated third molar extraction.

关 键 词：舍雷肽酶 下颌阻生智齿 牙拔除术 并发症 

分 类 号：R783[医药卫生—口腔医学]