在线电解生成次氯酸根-流动注射化学发光法测定盐酸阿糖胞苷  

Flow Injection Chemiluminescence Determination of Cytarabini Hydrochloridum with On-line Electrogenerated Hypochlorite

作　　者：晨晓霓[1] 张成孝[1] 吕九如[1] 

机构地区：[1]陕西师范大学化学系,西安710062

出　　处：《分析试验室》2000年第2期62-64,共3页Chinese Journal of Analysis Laboratory

基　　金：陕西省自然科学基金!资助项目 (98H0 3 )

摘　　要：将恒电流电解在线产生 Cl O-与流动注射化学发光分析法有效地结合 ,基于盐酸阿糖胞苷对 Cl O-- Luminol体系化学发光的拟制作用 ,建立了测定盐酸阿糖胞苷流动注射化学发光新分析法。该法测定盐酸阿糖胞苷的线性范围为 1× 1 0 -8～ 4× 1 0 -7g,检出限为 8× 1 0 -9g,相对标准偏差为 3.0 % ( n=1 1 ) ,已应用于注射用盐酸阿糖胞苷的测定。A novel flow injection chemiluminescence method for the determination of cytarabini hydrochloridum based on its inhibition of chemiluminescence from luminol hypochlorite system was described.The hypochlorite was electrogenerated on line by constant current electrolysis,resulting in eliminating instability of the hypochlorite solution prepared from commercially available sodium hypochlorite.The linear range for cytarabini hydrochloridum is from 1×10 -8 to 4×10 -7 g·L -1 and the detection limit is 8×10 -9 g·L -1 .The relative standard deviation is 3.0%.The proposed method with simplicity,rapidity and sensitivity was successfully applied to the determination of cytarabini hydrochloridum in pharmaceutical injections.

关 键 词：流动注射分析 化学发光 次氯酸根 盐酸阿糖胞苷 

分 类 号：R914.1[医药卫生—药物化学] O657.3[医药卫生—药学]