吗啉(哌嗪或六氢吡啶)取代的α-乙酰氨基膦酸二苯酯的研究  

Study on Morpholine (Piperidine or Piperazine) Substituted α-Acetylaminoalkylphosphonic Acid Diphenyl Esters

作　　者：李在国[1] 黄润秋[1] 邵瑞链[1] 马军安[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机国家重点实验室,天津300071

出　　处：《合成化学》2000年第2期130-133,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金! (No :2 9832 0 50 );天津市自然科学基金! (No :9836 0 2 71)

摘　　要：α 氨基膦酸二苯酯与氯乙酰氯反应得到α 氯乙酰氨基膦酸二苯酯 ,后者与吗啉、哌嗪或哌啶反应合成了饱和杂环取代的膦二肽。化合物的结构经元素分析和1HNMR证实。生物活性测试结果表明该类化合物对油菜具有一定的抑制作用。Some saturated heterocycle substituted phosphono dipeptides(3 and 4) were synthesized with α aminoalkylphosphonic acid diphenyl esters(1) as starting material. 1 were treated with chloroacetyl chloride to give α chloroacetylaminoalkylphosphonic acid diphenyl esters, which were substituted with morpholine, piperidine of piperazine to yield 3 or 4. The structures of compounds 3 and 4 were confirmed by elementary analysis and 1H NMR. The results of bioassay indicated that 3 and 4 have selective herbicidal activity at against rape.

关 键 词：植物生长调节剂 生物活性 Α-氨基膦酸酯 

分 类 号：TQ452.02[化学工程—农药化工]