多巴胺2受体基因TaqIA多态性与美沙酮维持治疗海洛因依赖患者心理症状相关性研究  

Association study between DRD2 TaqIA polymorphism and psychological symptoms of heroin addicts who have received methadone maintenance treatment

作　　者：黄飞[1] 郭艳红[1] 王静辉[1] 

机构地区：[1]山东省青岛市精神卫生中心,266034

出　　处：《四川精神卫生》2012年第2期70-73,共4页Sichuan Mental Health

摘　　要：目的研究昆明市美沙酮维持治疗A门诊接受美沙酮维持治疗的汉族海洛因依赖者多巴胺D2受体基因TaqIA多态性与接受美沙酮维持治疗海洛因依赖患者心理症状的相关性,探讨影响病人治疗效果的遗传因素。方法对81例接受美沙酮维持治疗的海洛因依赖者实施SCL-90测试,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术,检测多巴胺D2受体基因TaqIA基因多态,比较不同基因型与SCL-90各因子的关系。结果 A1+组(A1/A1,A1/A2)与A1-组(A2/A2)SCL-90各因子分无显著性差异。结论D2受体基因TaqIA多态性与美沙酮维持治疗海洛因依赖患者心理症状可能不存在相关性。Objective To investigate the relationship of DRD2 receptor gene TaqIA polymorphisms and psychological symptoms of heroin addicts who have received methadone maintenance treatment. Methods 81 heroin addicts who had received methadone maintenance treatment were given the self-reporting inventory（SCL-90）.And then we detected the polymorphism of DRD2 TaqIA for them by using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms（PCR-RFLP）technique.We compared the relationship between genotypes of DRD2 TaqIA and each psychological factor score of SCL-90. Results There is not statistical significances in each factor score of SCL-90 between the patients who carry allele A1（A1/A1＋A1/A2）and those who do not carry allele A1（A2/A2）. Conclusion DRD2 TaqIA polymorphism may have no association with psychological symptoms of heroin addicts who have received methadone maintenance treatment.

关 键 词：多巴胺受体基因 多态性 美沙酮维持治疗 心理症状 

分 类 号：R749.61[医药卫生—神经病学与精神病学]