抗核周型粒细胞胞浆抗体及抗小肠杯状细胞抗体在溃疡性结肠炎诊疗中的价值  

Value of Perinuclear Anti - neutrophil Antibody and Anti - intestinal Goblet Cell Antibody in Diagnosis and Treatment of Ulcerative Colitis

作　　者：谢靖[1,2] 韩英[1] 武子涛[1] 王志红[1] 

机构地区：[1]北京军区总医院消化内科,北京100700 [2]山西医科大学研究生院,山西太原030001

出　　处：《医学新知》2012年第2期99-101,104,共4页New Medicine

摘　　要：目的分析我国溃疡性结肠炎（UC）患者的临床特征，判断临床特征与血清型标记物抗核周型粒细胞胞浆抗体（pANCA）、抗小肠杯状细胞抗体（GAB）是否存在相关性。方法按照中国炎症性肠病诊断治疗规范的共识意见对117例UC患者进行诊断描述，并记录pANCA、GAB、肠外表现、手术情况，比较各亚型之间的差异。结果我国UC患者病变范围以全结肠和左半结肠（39．3％，23．9％）为主，中，重度（39．3％，38．5％）多见。有肠外表现者为7．1％。存在病变累及范围越广越严重的趋势，总体差异有统计学意义（P〈0．05）。pANCA，GAB在UC患者中的阳性率分别为50．4％，9．4％。结论pANCA、GAB阳性与性别、年龄、临床类型、病变范围、病情程度、肠外表现等无关（P〉0．05）。Objective To analyze the features of clinical classification of Chinese patients with ulcerative colitis （UC） , and to estimate the relationships between clinical features and Perinuclear anti - neutrophil antibody （pAN-CA）, and anti-intestinal goblet cell antibody（GAB）. Methods A retrospective study of 117 UC cases clinically di-agnosed by Chinese Consensus on diagnosis and treatment criteria of inflammatory bowel disease（IBD）. The results of pANCA, GAB, extra-intestinal manifestation, lesion range, lesion degree, were recorded and compared among different subtypes. Results The pancolitis and left-side （39.3%, 23.9% ）were predominantly noticed in Chinese UC pa-tients. Moderate and severe patients （39.3%, 38.5% ） were common. About 7. 1% of patients had extraintestinal manifestation. There was statistically difference in severity between the groups with different extent of lesion （ P 〈 0.05 ）. The positive rates of pANCA, GAB in patient with UC were 50.4% and 9.4%. Conclusions There was no sta-tistically important correlation between pANCA, GAB and gender, age, clinical types, ertraintestinal manifestations, le- sion range,lesion degree（ P 〉 0.05 ）.

关 键 词：溃疡性结肠炎 临床特征 抗核周型粒细胞胞浆抗体 抗小肠杯状细胞抗体 

分 类 号：R574.62[医药卫生—消化系统]