PI3K/Akt/mTOR信号通路与肿瘤  

Role of PI3K/Akt/mTOR signal transduction in tumor

作　　者：张丹丹[1] 李庆林[1] 

机构地区：[1]安徽中医学院.省部共建新安医学教育部重点实验室,安徽合肥230038

出　　处：《安徽医药》2012年第3期281-283,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然基金项目(No81173600);安徽省自然科学基金(No11040606M190)

摘　　要：在近年来的肿瘤治疗中,靶向生物治疗逐渐成为研究的热点。该文就磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白[phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/the mammalian target of Rapamycin(mTOR),PI3K/Akt/mTOR]信号通路予以综述,重点包括PI3K/Akt/mTOR信号转导在肿瘤机制中作用以及肿瘤治疗过程中耐药性方面的关系等。In recent years,targeted biological therapy has become an issue.In this paper,phosphatidylinositol-3-kinase（PI3K）/protein kinase B（Akt）/the mammalian target of Rapamycin（PI3K/Akt/mTOR） were reviewed.And in this review,the highlights are the role of PI3K/Akt/mTOR signal transduction in tumor cells and the relationship between drug resistances and PI3K/Akt/mTOR signal transduction during treatment.

关 键 词：PI3K/AKT/MTOR 信号传导 耐药性 

分 类 号：R730.2[医药卫生—肿瘤]