CCR5基因启动子59029位点单核苷酸多态性与HIV-1疾病进展关系的Meta分析  

Association between single nucleotide polymorphisms of the CCR5 gene promoter 59029 loci and HIV-1 disease progression: a Meta-analysis

作　　者：朱文昌[1] 聂军[1] 王云芸[1] 李建栋[1] 陈清[1] 俞守义[1] 

机构地区：[1]南方医科大学公共卫生与热带医学学院流行病学系,广东广州510515

出　　处：《热带医学杂志》2012年第5期534-537,共4页Journal of Tropical Medicine

基　　金：十一五国家科技攻关重大项目(2009ZX10001-0187);广州市科技攻关重点项目(2006Z1-E0091)

摘　　要：目的探讨CCR5基因启动子59029位点单核苷酸多态性(SNPs)与HIV-1感染者疾病进展的关系。方法按照制定的检索策略,在PubMed、CBM、VIP等数据库检索有关CCR5基因启动子59029位点SNPs与HIV-1感染者疾病进展关系的研究,按照纳入和排除标准选取文献,评价文献质量,提取相关数据。用Stata 10.0统计软件对数据进行Meta分析。结果按照纳入和排除标准,共纳入4个病例对照研究,其中长期不进展者(LTNP)总例数375人,快速进展者(RP)总例数282人。Meta分析结果显示,在排除了CCR5Δ32和CCR2-64I突变后,RP组的59029A/A纯合子基因型频率是0.235,高于LTNP组的0.144,两者差异具有统计学意义(Z=2.37,P=0.018),OR及95%CI是3.441(1.236,9.582)。RP组的59029A等位频率是0.513,也高于LTNP组的0.370(Z=3.13,P=0.002)。结论 CCR5基因启动子59029A等位与HIV-1疾病的快速进展相关。Objective To explore the association between single nucleotide polymorphisms of the CCR5 gene promoter 59029 loci and HIV-1 disease progression.Methods According to search strategy,all studies about association between CCR5 gene promoter 59029 loci SNPs and HIV-1 disease progression were searched in the PubMed,CBM,VIP et al.Literatures were selected according to inclusion and exclusion criteria,then assessing quality of the studies and extracting the relevant data.Using Stata 10.0 software for Meta-analysis,and assessing publication bias.Results According to inclusion and exclusion criteria,4 case-control studies were included,a total of 375 long-term non-progressor（LTNP） cases and 282 rapid progressor（RP） cases.In the exclusion of CCR5Δ32 and CCR2-64I mutation,Meta analysis revealed that 59029A/A homozygous genotype frequency in RP group was 0.235,significantly higher than that in LTNP group（0.144）（Z=2.37,P=0.018）,and OR（95%CI） was 3.441（1.236,9.582）.59029A allele frequency in RP group was 0.513,significantly higher than that in LTNP group（0.370）（Z=3.13,P=0.002）.Conclusion The CCR5 gene promoter 59029A allele was related to HIV-1 disease rapid progression.

关 键 词：CCR5 启动子 HIV 单核苷酸多态性 META分析 

分 类 号：R512.91[医药卫生—内科学]