CEA、NSE及CYFRA21-1与非小细胞肺癌术后病理分期的研究  

Study of CEA,NSE,CYFRA21-1 and Pathological Staging after Operation in Patients with Non-Small Cell Lung Cancer

作　　者：李志[1] 孙大强[2] 王晓东[1] 

机构地区：[1]天津医科大学,300070 [2]天津市胸科医院

出　　处：《天津医药》2012年第6期566-568,共3页Tianjin Medical Journal

基　　金：天津市卫生局科技基金资助项目(项目编号:09KY30)

摘　　要：目的:研究癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)及细胞角蛋白19片段(CYFRA21-1)肿瘤标志物在非小细胞肺癌中的联合表达,探讨其与可手术的非小细胞肺癌患者术后病理分期的相关性。方法:收集143例非小细胞肺癌患者的术后病理资料,所有患者术前均检测血清中CEA、NSE及CYFRA21-1的浓度,分析其表达结果与术后病理分期之间的关系。结果:血清CEA、CYFRA21-1的浓度在不同的T、N分期及不同淋巴结转移组数的患者中差异均有统计学意义(P<0.05或P<0.01);血清NSE浓度只在T1与T3期差异有统计学意义(P<0.05),而在不同病理N分期之间差异无统计学意义(P>0.05)。结论:术前检测非小细胞肺癌患者血清CEA、CYFRA21-1的浓度对准确判断非小细胞肺癌分期有重要的临床意义。Objective： To investigate the union expression of carcinoembryonic antigen（CEA）, neuron-specific enolase （NSE） and cytokeratin 19 fragment（CYFRA21-1） in non-small cell lung cancer and to explore the relationship between the tu- mor markers and the pathological staging of non-small cell lung cancer. Methods： The postoperative pathological data was collected in 143 patients with non-small cell lung cancer. The expression results of CEA, NSE and CYFRA21-1 were mea- sured before operation in all patients, which were used to study the correlation between them and postoperative pathological staging. Results： The levels of serum CEA and CYFRA21-1 were significantly different in patients with T and N stages and different numbers of lymphnode metastasis （P 〈 0.05 or P 〈 0.01）. The levels of serum NSE were significantly different in pa- tients with TI and T3 stages （P 〈 0.05）, but there was no significant difference between different pathological N stages （P 〉 0.05）. Conclusion： Preoperative detection of the serum concentration of CEA and CYFRA21-1 has important clinical signifi- cance in the accurate judgment of tumor staging in patients with non-small cell lung cancer.

关 键 词：癌 非小细胞肺 肿瘤分期 癌胚抗原 肿瘤标记 生物学 角蛋白质类磷酸丙酮酸水合酶 

分 类 号：R[医药卫生]