2步酯化法合成肉豆蔻酸甲酯的工艺研究  

Preparation of Methyl Myristate by a Two-Step Esterification Method from Myristic Acid

作　　者：周晓庆[1] 王昌梅[1] 张无敌[1] 陈玉保[1] 尹芳[1] 李建昌[1] 徐锐[1] 刘士清[1] 

机构地区：[1]云南师范大学,云南昆明650092

出　　处：《云南民族大学学报（自然科学版）》2012年第3期170-173,共4页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：云南省应用基础研究基金(2010CD050);云南省教育厅科学研究基金(2011Z028);云南省能源局项目(20102127);云南省工业与信息委员会项目(2011292)

摘　　要：以肉豆蔻酸和甲醇为原料,浓硫酸为催化剂,采用2步酯化法合成肉豆蔻酸甲酯.实验结果表明,其最佳工艺参数为:冷凝回流酯化阶段(第1阶段)甲醇的质量分数为80%,催化剂质量分数为0.5%,反应温度为(65±2)℃,反应时间为90 min,酯化率为90.03%;甲醇连续流加酯化阶段(第2阶段)甲醇流速为1.0 mL/min,反应温度为(100±5)℃,反应时间为30～60 min,最终转化率为98.19%.并采用正交法进行验证,得到的单因素实验工艺参数可靠.本实验具有反应时间短,能耗低,转化率高,工艺简单等优点.Using myristic acid and methanol as raw materials and the catalyst is concentrated sulfuric acid, doing the experimental by two - step esterification. The result of the experimental is ： in the stage of methanol refluxing （the firs stage）, the amount of methanol to myristic acid is 80%, the quality of catalyst to myristic acid is 0.5%, temperature is （65 ±2）℃, reaction time is 90min, and the esterification ratio is 90.03%. In the stage for continuous to join methanol （ the second stage）, the flow velocity of methanol is 1.0mL/min, temperature is （ 100 ±5 ）℃, reaction time is 30-60 min, and the finally esterification ratio is 98.19%. Using orthogonal experiment to check the single factor experimental process parameters is feasible. The experimental has many advantages, such as saving time, low power, high conversion, simple process and so on.

关 键 词：肉豆蔻酸 肉豆蔻酸甲酯 正交法 

分 类 号：S216[农业科学—农业机械化工程]