H型高血压患者血清B族维生素水平以及脑影像学变化的研究  

Vitamin B levels in blood serum and brain MRI changes in patients with H-type hypertension

作　　者：樊敬峰[1] 刘萍[1] 曹秀丽[1] 

机构地区：[1]大连市友谊医院神经内一科,116001

出　　处：《中华神经医学杂志》2012年第6期619-621,共3页Chinese Journal of Neuromedicine

摘　　要：目的观察H型高血压患者血浆同型半胱氨酸（Hcy）及血清叶酸、维生素B12和患者脑白质的变化，为临床干预脑白质病变提供参考依据。方法选择大连市友谊医院神经内科、心内科自2010年4月至2011年3月收治的高血压患者110例（其中H型高血压组78例，单纯高血压组32例），选择同期健康体检者50例作为对照组，采用放射免疫分析法检测血浆Hcy及血清叶酸、维生素B12的水平，MRI检查并评价脑白质病变的级别。结果H型高血压患者血浆Hcy、血清叶酸、维生素B12水平高于单纯高血压组和对照组，差异有统计学意义（P〈0．05）；3组受试者脑自质病变级别的差异有统计学意义（P〈0．05），由平均秩次判断，脑白质病变在H型高血压组表现明显，其次为单纯高血压组、对照组。结论H型高血压患者血中叶酸、维生素B12水平下降，脑白质病变损害严重，可能与高Hcy血症有关。Objective To investigate the levels of plasma homocysteine （Hcy）, serum folic acid and serum vitamin B12 in patients with H-type hypertension to provide some reference for intervening the white matter lesions. Methods One hundred and ten patients with hypertension （78 with H-type hypertension and 32 with hypertension）, admitted to our hospital fi＇om April 2010 to March 201 I, and other 50 healthy controls were chosen in our study; plasma Hey level and serum folic acid and vitamin B12 levels were measured by using radioimmunoassay among control group, hypertension group and H-type hypertension group. White matter lesion changes of all patients were evaluated by MRI. Results The plasma Hcy level and serum folic acid and vitamin B12 levels in H-type hypertension group were significantly higher than those in control group and hypertension group （P〈0.05）; the degree of white matter lesions was significantly different between each 2 groups （P〈0.05）： the patients of H-type hypertension group had the most obvious white matter lesions, following by hypertension group and control group. Conclusion The patients with H-type hypertension have decreased folic acid and vitamin B12 levels and severe white matter lesion changes, which might be correlated with hyperhomocysteinemia.

关 键 词：H型高血压 叶酸 维生素B12 脑白质病变 

分 类 号：R743.3[医药卫生—神经病学与精神病学]