表皮生长因子受体与核因子κB p65在舌鳞状细胞癌组织中表达及相关性研究  

Expression and clinical significance of EGFR and NF-κB p65 in tongue squamous cell carcinoma

作　　者：李正红[1] 李德超[2] 薛洪池 

机构地区：[1]佳木斯市中心医院口腔颌面外科,黑龙江佳木斯154002 [2]佳木斯大学口腔医院口腔颌面外科,黑龙江佳木斯154004

出　　处：《中国实用口腔科杂志》2012年第5期287-290,共4页Chinese Journal of Practical Stomatology

基　　金：黑龙江省人事厅留学回国人员科技项目择优资助基金(黑人发[2009]23号);黑龙江省自然科学基金面上项目(D201025)

摘　　要：目的探讨表皮生长因子受体(EGFR)与核因子-κBp65(NF-κBp65)在舌鳞状细胞癌(TSCC)中的表达特征及二者间的相关性。方法选取2002年1月至2009年12月佳木斯大学第二附属医院(口腔医院)口腔颌面外科手术切除TSCC组织标本43例;另选择来源于同期因舌部良性病变而手术切除的病变周围正常舌组织标本15例。采用免疫组化法检测组织中EGFR、NF-κBp65的表达。结果 TSCC组织中EGFR、NF-κBp65的阳性表达率分别为72.1%、67.4%。TSCC患者EGFR和NF-κBp65的表达在不同性别、年龄、病理组织分型方面差异无统计学意义(P>0.05),而在TNM分期及有无淋巴结转移方面差异有统计学意义(P<0.05)。EGFR与NF-κBp65表达呈正相关关系(r=0.741,P<0.01)。结论 EGFR和NF-κBp65在TSCC组织中呈过表达,二者的联合检测可以作为判断TSCC生物学行为和指导临床治疗的指标。Objective To explore the expressions of EGFR and NF-KB p65 in tongue squamous cell carcinoma and the correlation between EGFR and NF-kB p65. Methods lmmunohistochemistry SP method was performed to measure the situation expression in 43 cases of TSCC and 15 cases of nomal tongue tissue. Results The positive expression rate of EGFR and NF-kB p65 was 72.1% and 67.4% in tumor tissue samples, higher than that in normal tissue samples（P 〈 0.01 ）.The expression of EGFR and NF-kB p65 was correlated with TNM stages and lymph node metastases （P 〈 0.05）, and neither of them Was correlated with age and sex（P 〉 0.05）. The level of EGFR protein positively correlated with that of NF-kB p65 （r = 0.741,P 〈 0.01） o Conclusion EGFR and NF-kB p65 are overexpressed in TSCC ;it is closely cor- related with its occurrence and development. And both of them jointly may be indicator to determine biological behaviors and clinical therapy of TSCC.

关 键 词：舌鳞状细胞癌 表皮生长因子受体 NF-ΚBP65 免疫组化 

分 类 号：R78[医药卫生—口腔医学]