糖皮质激素参与疼痛信号调控的研究进展  

Progress in involvement of glucocorticoids in pain signals modulation

作　　者：阚会丽[1] 张宗旺[2] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室＆江苏省麻醉与镇痛应用技术重点实验室,221002 [2]聊城市人民医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2012年第6期416-419,共4页International Journal of Anesthesiology and Resuscitation

基　　金：山东省医药卫生科技发展计划课题（2007HZ015）

摘　　要：背景糖皮质激素用于临床急、慢性疼痛的治疗已有几十年历史，糖皮质激素受体通过多种机制参与了疼痛信号转导过程。目的更好地了解糖皮质激素是如何通过细胞内信号分子而发挥镇痛作用，指导临床合理应用糖皮质激素。内容从其抑制炎症反应和疼痛介质的产生，以及作用于一些相关受体，甚至参与阿片耐受机制等方面作一总结。趋向目前对糖皮质激素的研究尚存在很多争议，研究其具体作用机制仍是基础研究的靶点之一。Background In recent decades, the glueocorticoids has been used widely to treat acute or chronic pain. Recent research finds that glucocorticoid receptors are involved in pain signal pathways through many mechanisms. Objective To better understand the intracellular glucoeorticoid mechanism of analgesia and guide clinical application. Content This article summarizes the roles of glucocorticoid in inhibiting the production of inflammatory factors and pain transmitters, discusses its impacts on the receptors related with pain and its suppression of opioid tolerance. Trend At present, there are some diputes in glucocorticoid research. It＇s one of the targets of basic research to study the special mechanism of glucocortieoid underlying pain signal pathways.

关 键 词：糖皮质激素 疼痛 P2X受体 阿片耐受 

分 类 号：R363[医药卫生—病理学]