肌动蛋白结合蛋白transgelin-2在结直肠癌中的表达及其意义  

Expression of transgelin-2 and clinical significance in colorectal cancer

作　　者：禚洪庆[1] 张彦斌[1] 张辉[1] 郭鹏[1] 吕游[1] 董令仪[1] 姜可伟[1] 叶颖江[1] 王杉[1] 

机构地区：[1]北京大学人民医院胃肠外科外科肿瘤实验室,100044

出　　处：《中华外科杂志》2012年第6期551-554,共4页Chinese Journal of Surgery

基　　金：高等学校博士学科点专项科研基金资助项目（20090001110089）

摘　　要：目的探讨结直肠癌组织中肌动蛋白结合蛋白transgelin-2的表达及其与临床病理因素的关系，评价transgelin-2在结直肠癌预后判断中的价值。方法应用组织芯片结合免疫组化方法，检测2002年9月至2004年4月120例手术切除的结直肠癌患者组织中transgelin-2的表达情况，男性74例，女性46例，年龄26—89岁，中位年龄64．5岁。采用x。检验其与临床病理因素的关系，Log-rank检测生存率差别，Cox比例风险模型分析多个变量对生存时间的影响。结果transgelin-2在结直肠癌组织中的阳性表达率为69．2％。transgelin-2的表达与分化程度（X。=5．420）、淋巴结转移（x2=45．577）、远处转移（x2=12．009）及TNM分期（x2=47．577）相关（P〈0．05）。transgelin-2阳性表达者术后生存时间（39±5）个月，阴性表达者为（59±3）个月，Kaplan—Meier生存分析显示，transgelin-2表达与生存时间密切相关（P=0．003）。Cox分析显示，远处转移（RR=8．318，95％CI：4．119～16．790）、淋巴结转移（RR=2．794，95％CI：1．246—6．263）和transgelin-2表达（RR=1．834，95％CI：1．118～2．793）是影响结直肠癌患者预后的独立因素（P〈0．05）。结论肌动蛋白结合蛋白transgelin-2的表达水平与结直肠癌临床病理因素及预后相关，可能成为判断结直肠癌转移和预后的潜在标志物。[ Abstract] Objectives To investigate the relationship between the expression of transgelin-2 and the clinicopathological factors of colorectal carcinoma and evaluate the value of transgelin-2 in prognostic assessment of the colorectal cancer patients. Methods Using tissue microarray and immunohistochemical methods, we examined transgelin-2 of 120 colorectal cancer patients received surgical treatment from September 2002 to April 2004, including 74 male and 46 female, age from 26 to 89 years. Analyzed the relationship between transgelin-2 and both the clinicpathologcial features and prognosis of the colorectal cancer by using X2 test and Kaplan-Meier survival analysis. Cox proportion hazard regression analysis was used to study the independent prognostic factors. Results The positive rate of transgelin-2 expression was 69.2% in colorectal carcinoma. The transgelin-2 expression correlated with differentiation degree （ X2 = 5.420） , lymph nodes metastasis （ X2 = 45. 577 ）, distant metastasis （ X2 = 12. 009 ）, and TNM staging （ X2 = 47. 577 ）. The survival time was （ 39 ：l： 5 ） months in patients with positive expression of the trangelin-2, while （59 ~ 3 ） months in patients with negative expression. The patient＇s survival time was statistically correlated with the transgelin-2 expression （P = 0. 003 ）. Distant metastasis （RR = 8. 318, 95% CI： 4. 119-16. 790 ）, lymph nodes metastasis （ RR = 2. 794, 95% CI： 1. 246-6. 263 ） and transgelin-2 expression （RR = 1. 834, 95% CI： 1. 118-2. 973 ） were independent prognostic factors in patients with colorectal cancer （P 〈 0. 05 ）. Conclusions The expression of transgelin-2 is correlated with clinicopathological features and prognosis in coloreetal cancer, may be the potential marker of metastasis and the prognosis of coloreetal cancer patients.

关 键 词：结直肠肿瘤 微丝蛋白质类 肌蛋白质类 免疫组织化学 组织阵列分析 预后 

分 类 号：R735[医药卫生—肿瘤]