腹膜后脂肪肉瘤外科治疗及其术后复发的多因素分析  

Surgical management and factors associated with postoperative recurrence for retroperitoneal liposarcoma:a multivariate analysis

作　　者：郝玉娟[1] 罗成华[1] 郑伟[2] 宋少柏[2] 

机构地区：[1]首都医科大学附属北京世纪坛医院结直肠肛门外科,北京100038 [2]解放军总医院普通外科,北京100853

出　　处：《外科理论与实践》2012年第3期275-280,共6页Journal of Surgery Concepts & Practice

基　　金：北京市科委"首都市民健康项目培育"项目(Z111107067311063)

摘　　要：目的:探讨腹膜后脂肪肉瘤(RPLS)的诊疗经验,并寻找影响RPLS术后复发的因素。方法:收集并回顾性分析84例RPLS病人临床病理特征、外科处理方法及影响术后复发的因素。结果:84例病人共行手术110例次,肿瘤完全切除72例次(65.5%),联合周围脏器切除66例次(60.0%)。术后总复发率64.3%,中位复发时间10个月。多因素分析显示RPLS分化程度和肉眼完全切除是影响术后复发的独立因素。联合脏器切除组与单纯肿瘤切除组的肉眼完全切除率分别为72.7%、54.5%,差异有统计学意义(P<0.05)。结论:RPLS术后复发率高,肿瘤分化程度和肉眼完全切除是影响RPLS术后复发时间的独立因素。联合周围脏器的肿瘤切除可明显提高肿瘤的完全切除率。Objective To investigate the experiences of retroperitoneal liposarcoma （RPLS） clinicopathological and surgical factors associated with postoperative recurrence. Methods management, and Clinicopathological characteristics and surgical management were reviewed retrospectively. Multivariate analysis of factors with postoperative recurrence were performed. Results One hundred and ten operations were performed on all 84 cases with RPLS, of which 72 undertaken gross complete resection （65.5%）, 66 undertaken the resection involved organs （60.0%）. Postoperative recurrence rates were 64.3% and median recurrence-free time were 10 months. Multivariate analysis showed that tumor differentiation and gross complete resection were independent factors affecting recurrence-free time in RPLS. Group of the resection involved organs gained a higher gross complete resection rate than simple tumor resection group （72.7% vs 54.5%, P〈0.05）. Conclusions RPLS has high postoperative recurrence rate. Tumor differentiation and gross complete resection are independent factors affecting recurrence-free time in RPLS. The resection involved organs is often required to increase the complete resection rate.

关 键 词：腹膜后肿瘤 脂肪肉瘤 外科治疗 复发 多因素分析 

分 类 号：R735.4[医药卫生—肿瘤]