白细胞介素-18与肿瘤侵袭转移相关性的研究现状  

Research status of relationship between IL-18 and tumor invasion and metastasis

作　　者：邵奇[1] 王宁[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经外科,黑龙江哈尔滨150001

出　　处：《中华肿瘤防治杂志》2012年第7期547-551,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：黑龙江省科学技术厅基金(2007L0037-00)

摘　　要：目的:总结白细胞介素-18(IL-18)与肿瘤的侵袭、转移之间关系的研究现状,探讨其在肿瘤侵袭、转移中的重要作用机制。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"IL-18,白细胞介素-18,肿瘤"等为关键词,检索2005-01-01-2012-03-31相关文献,共检到文献680条。纳入标准:1)IL-18促进肿瘤侵袭、转移的机制;2)IL-18抑制肿瘤侵袭、转移的机制;3)IL-18在不同肿瘤中的异常表达与预后。根据纳入标准符合分析的文献41篇。结果:IL-18主要通过免疫调节、影响肿瘤血管生成和对细胞因子及其受体的调节等多种复杂机制来实现对肿瘤生物学行为的介入。当IL-18表现为免疫激活或是抑制肿瘤血管生成活性时,主要发挥其抑制肿瘤的作用;当IL-18在免疫逃逸、细胞外基质降解、肿瘤细胞黏附和肿瘤血管生成等方面表现为促进作用时,其亲肿瘤效应尤为显著。但是IL-18在不同肿瘤中上调或下调的具体机制尚不清楚。IL-18与VEGF、黏附分子、趋化因子、M-CSF、TNF和MMPs等其他肿瘤侵袭转移相关因子间的关系及信号转导机制也需进一步完善。结论:IL-18在肿瘤侵袭转移中的作用具有两面性,其具体的调控机制和作用条件需要更加深入地研究和综合分析。OBJECTIVE： To summarize the research status of the relationship between IL-18 and tumor invasion and metastasis, and explore the important effects and complicated mechanisms of IL-18 in tumor invasion and metastasis. METHODS： A total of 680 papers were searched with IL-18 and tumor as key words in PubMed and CNKI database from 2005-01-01--2012-03-31. Forty-one papers of literature are selected and analyzed according to the inclusion criteria as fol- lows： 1）The mechanism of tumor invasion and metastasis promoted by IL-18. 2）The mechanism of tumor invasion and metastasis inhibited by IL-18. 3）The abnormal expression and prognostic value of IL-18 in different tumors. RESULTS： IL-18 implement the impact of tumor biological behavior mainly through a variety of complex mechanisms,including immune regulation, influenee of tumor angiogenesis and modulation of cytokines and their receptors. IL-18 mainly play its role in inhibition of tumor when performing immune activation or inhibiting tumor angiogenesis, However, IL-18 will remarkably display its promoting tumor effect when advancing immune escape, extracellular matrix degradation, tumor cell adhesion and tumor angiogenesis, but the explicit mechanisms in different tumors is still unclear. Furthermore, there is also a necessity to clari[y the relationship and signal transduetion mechanism between IL-18 and other tumor invasion- metastasis correlated factors, for instance VEGF,adhesion molecules,chemotatic factor, M-CSF,TNF and MMPs etc. CONCLUSION： Although IL-18 has dual characters in tumor invasion and metastasis, the complicated regulation mechanism and effect condition should be studied deeply and analyzed synthetically.

关 键 词：白细胞介素-18 肿瘤侵袭 肿瘤转移 综述文献 

分 类 号：R730.2[医药卫生—肿瘤]