硒酵母对阿尔茨海默病患者血清一氧化氮,超敏C反应蛋白的影响  

Effects of Selenium Yeast on Serum Nitric Oxide and High-sensitivity C-reactive Protein in Patients with Alzheimer Disease

作　　者：徐进亮[1] 李亮[1] 王建华[1] 毕建波[1] 曲忠森[2] 

机构地区：[1]潍坊医学院附属青岛市胶州中心医院,青岛266300 [2]上海交通大学附属第六人民医院,上海200233

出　　处：《中国医药导刊》2012年第1期83-84,共2页Chinese Journal of Medicinal Guide

基　　金：中国博士后科学基金(200603900635)

摘　　要：目的:观察硒酵母对阿尔茨海默病患者一氧化氮及超敏C反应蛋白的影响。方法:将60例阿尔茨海默病患者随机分为阿尔茨海默病组(20例),治疗组(20例)和对照组(20例),治疗组和对照基础治疗相同,治疗组在对照组基础治疗上加服硒酵母胶囊,用硝酸还原法及免疫散射比浊法检测血清NO及hs-CRP的水平。结果:与对照组比较,治疗组升高NO(P<0.05),降低hs-CRP水平更明显(P<0.05)。结论:硒酵母可能对AD患者炎症反应诱导的血管内皮功能损伤有潜在的修复作用。Objective：To observe the effcts of selenium yeast on nitric oxide and high-sensitivity C-reactive protein in patients with Alzheimer disease（AD）.Methods：The levels of nitric oxide and high-sensitivity C-reactive protein were measured in AD group,control group,and treatment group.Results：As compared with the control group,the level of NO was decreased and the level of hs-CRP was increased in treatment group（P0.05,P0.05）.Conclusion：Selenium yeast might recovery the vascular endothelial dysfunction induced by chronic inflammation in patients with AD.

关 键 词：硒酵母 阿尔茨海默病 一氧化氮 C-反应蛋白 

分 类 号：R749.16[医药卫生—神经病学与精神病学]