非小细胞肺癌患者O6-甲基鸟嘌呤-DNA甲基转移酶的表达及意义  

Expression and Clinical Significance of O6-methylguanine-DNA Methyltransferase in NSCLC Patients

作　　者：金文波[1] 郑梦利[1] 祁彦君[1] 马连君[1] 周乃康[1] 

机构地区：[1]解放军第309医院胸外科,北京100091

出　　处：《中国医药导刊》2012年第4期657-658,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨非小细胞肺癌MGMT表达的临床病理意义。方法:应用免疫组化方法检测90例非小细胞肺癌癌组织中MGMT的表达,并以60例肺癌周围正常组织作为对照。结果:在90例非小细胞肺癌患者肿瘤组织中MGMT的表达率为53.33%(48/90),明显低于肺癌周围正常组织的76.67%(46/60)(P=0.0065);非小细胞肺癌患者肿瘤组织中,MGMT的阳性表达率在吸烟组为72.73%(40/55),明显高于不吸烟组的22.86%(8/35)(P=0.0000);在低分化组为35.0%(14/40),明显低于高、中分化组的68.0%(34/50)(P=0.0037);但与患者性别、年龄、肿瘤大小、病理类型、淋巴结转移及TNM分期均无明显相关性(P>0.05)。结论:非小细胞肺癌中,MGMT的阳性表达与肺癌的发生、发展相关,其监控有助于肺癌的预防及早期诊断。Objective： To investigate the clinical value of O6-methylguanine-DNA methyltransferase（MGMT） expression in non small cell lung cancer（NSCLC）.Methods： The MGMT gene expression in 90 cases of NSCLC and 60 cases of tissue adjacent to the tumor were detected by immunohistochemical method and the correlation between the expression and clinical factors was analyzed.Results： The positive rates of MGMT in NSCLC（53.33%） was significantly lower（P =0.0065） than the tissue adjacent to the tumor（76.67%）.In lung carcinomas,the positive rate of MGMT in the groups with smoking history（72.73%） was significantly higher（P= 0.0000） than the group without smoking history（22.86%）.The expression rate of MGMT in the groups of poor differentiation（35.0%） was significantly lower（P=0.0037） than the groups of well or media differentiation（68.0%）.But the positive rate of MGMT had no relationship with gender,age,tumor dimension size,lymph node metastasis,histology and TNM stage（P 0.05）.Conclusion： MGMT gene is related in the occurrence,development of NSCLC,and it can be as a marker to diagnose and predict NSCLC.

关 键 词：非小细胞肺癌 O6-甲基鸟嘌呤-DNA甲基转移酶 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]