三种新型可聚合抗菌单体对口腔病原菌的抗菌活性研究  

Antibacterial activities of three new polymerizable quaternary ammonium salt monomers on oral pathogenic bacteria

作　　者：周唯 唐立辉 黄萍 黄鹂 李芳 方明 陈吉华 

机构地区：[1]第四军医大学口腔医院口腔修复科,西安710032 [2]第四军医大学口腔医院口腔材料教研室,西安710032 [3]第四军医大学口腔医院检验科,西安710032

出　　处：《实用口腔医学杂志》2012年第3期298-301,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81130078;81070861;81100772)

摘　　要：目的:比较自行合成的3种可聚合季铵盐抗菌单体DMAE-MMA salt,DMAEMA-MMA salt,DMAEMA-PMDPM salt对口腔常见致病菌的抗菌活性。方法:采用液体稀释法测定季铵盐单体对4种口腔常见致病菌的抗菌活性,以抗菌性能最佳的单体进行杀菌动力学研究。结果:3种季铵盐单体对4种口腔致病菌均表现出一定的抗菌活性,其中DMAEMA-PMDPM salt抗菌效果较其它2种好,该单体在浓度为78.8 mg/ml即4倍MBC浓度时,白色念珠菌与其接触120 min时可达到灭菌效果。结论:这3种季铵盐单体对常见口腔致病菌均表现出一定的抗菌活性。Objective： To compare the antibacterial activities of three polymerizable quaternary ammonium salt monomers,DMAE-MMA salt,DMAEMA-MMA salt and DMAEMA-PMDPM salt,on oral pathogenic bacteria.Methods：The antibacterial activities of the monomers were investigated by using the broth dilution test on 4 oral pathogenic bacteria.The most effective monomer was further tested for time-dependent effects.Results：Three monomers showed bactericidal activities against 4 bacteria.The MBC value of DMAEMA-PMDPM salt was the lowest,ranging from 0.078 to 19.700 mg/ml.Almost all of the bacteria can be killed in 120 min by DMAEMA-PMDPM salt at 78.8 mg/ml（4×MBC）.Conclusion：The 3 monomers have antibacterial activities.

关 键 词：季铵盐 单体 口腔致病菌 抗菌活性 树脂类材料 

分 类 号：R783[医药卫生—口腔医学]