新辅助化学疗法对结直肠癌患者炎症水平的影响  

The Influence of Neo-adjuvant Chemotherapy on the Chemokine Level in Patients with Colorectal Neoplasms

作　　者：王彬[1,2] 唐之韵[1,2] 彭驰涵[1,2] 汪晓东[2,3] 李立[2,3] 

机构地区：[1]四川大学华西临床医学院,成都610041 [2]四川大学华西医院MCQ团队,成都610041 [3]四川大学华西医院胃肠外科中心,成都610041

出　　处：《华西医学》2012年第5期697-700,共4页West China Medical Journal

基　　金：四川大学CMB医学教育研究与发展中心项目(CMB-00-721)

摘　　要：目的探讨新辅助化学疗法(化疗)对结直肠癌手术患者炎症因子水平的影响。方法回顾2008年1月-2009年12月诊断为结直肠癌的487例患者的临床资料,剔除不符合研究条件者后,共390例,以是否接受过新辅助化疗分为术前化疗组(化疗组)156例与对照组234例进行研究。分别比较两组在入院时、术前、术后的炎症因子水平。结果入院时两组外周血白细胞、C反应蛋白(CRP)、纤维蛋白原、血清淀粉样蛋白水平差异均无统计学意义(P>0.05);术后化疗组CRP水平[(64.09±60.24)mg/L]低于对照组[(87.80±61.54)mg/L],差异有统计学意义(P<0.05);其余炎症因子组间差异无统计学意义(P>0.05)。结论新辅助化疗不会刺激机体产生免疫反应,且有一定的安全性。Objective To evaluate the security of neo-adjuvant chemotherapy by testing the level of such nonspecific chemokines as C-reactive protein （CRP）, fibrinogen （FIB） and serum amyloid A （SAA）. Methods There were 487 patients with colorectal cancer accepted in West China Hospital between January 2008 and December 2009, and 97 of them didn＇t conform to the study including standard. The rest 390 patients were assigned to 2 groups, including 156 in the control group and 234 in the neo-adjuvant chemotherapy group. The level of chemokines were measured and compared between the two groups at the time of acceptance, before and after surgery. Results The increase of CRP after the surgery was signifigantly higher in the neo-adjuvant chemotherapy group [（87.80 ± 61.54） mg/L] than that in the chemotherapy group [（64.09 ± 60.24） rag/L）] （P 〈 0.05）. The level of WBC, CRP and SAA increased after the surgery compared with the time of the acceptance （P 〈 0.05）. Conclusion The neo-adjuvant chemotherapy will not irritate the immune system, which may be considered as a therapy of certain safety.

关 键 词：新辅助化学疗法 结直肠肿瘤 炎症趋化因子 

分 类 号：R735.3[医药卫生—肿瘤]