食管腺癌、Barrett食管活检粘膜中TGF-β1的表达  

Expression of TGF-β1 of the Esophageal Mucosa of Patients with Esophageal Adenocarcinoma or Barrett Esophagus

作　　者：甄云飞[1] 曲海霞[1] 王青[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院消化科(东院),山东青岛266071

出　　处：《现代生物医学进展》2012年第10期1941-1942,1933,共3页Progress in Modern Biomedicine

摘　　要：目的:研究食管腺癌、Barret食管(Barrett esophagus,BE)和正常食管粘膜中转化生长因子β1(transforming growth factor-betal,TGF-β1)的表达。方法:采用免疫组化方法检测35例食管腺癌患者、40例BE患者及30例健康对照组食管组织中TGF-β1的表达水平。结果:未在健康对照组食管粘膜中发现TGF-β1的表达,食管腺癌组TGF-β1的表达水平>BE组>健康对照组(P<0.05)。食管腺癌组中,TGF-β1在中-高分化腺癌及低分化腺癌患者食管粘膜中的表达无明显差异(Z=1.07,P>0.05)。结论:食管腺癌、BE食管粘膜中TGF-β1表达水平升高,在食管腺癌中的表达与细胞分化程度无关。Objective： To investigate the expression of TGF-β1 of the esophageal mucosa of patients with esophageal adenocarcinoma or Barrett esophagus（BE）.Methods： Thirty five cases in esophageal adenocarcinoma,forty cases in BE,thirty cases in the control group were enrolled the test.The expression of TGF-β1 of all specimens was detected by immuno-histochemistry.Results： There was no expression of TGF-β1 in the normal esophageal mucosa.The expression of TGF-β1 in the esophageal adenocarcinoma group BE group control goup（P0.05）.In the esophageal adenocarcinoma group,no significant difference was found in the expression level of TGF-β1 in moderately-differentiated or well-differentiated specimens with the poorly-differentiated ones（Z=1.07,P0.05）.Conclusions： There was a high expression of TGF-β1 in the esophageal mucosa of patients with esophageal adenocarcinoma or Barrett esophagus（BE）.There was no association between the expression of TGF-β1 and the degree of cellular differentiation in the esophageal mucosa of patients with esophageal adenocarcinoma.

关 键 词：食管腺癌 BARRETT食管 转化生长因子Β1 免疫组织化学 

分 类 号：R571[医药卫生—消化系统]