载体助溶剂协同超临界二氧化碳萃取迷迭香抗氧化活性成分的研究  

Study on the extraction of the antioxidant components in rosemary using supercritical CO2 fluid combined with a cosolvent carrier

作　　者：刘杰[1,2] 曾健青 李卫民[1] 高英[1] 陈瞾[2] 

机构地区：[1]广州中医药大学,广州510006 [2]广州和博生物科技有限公司,广州510507

出　　处：《北方药学》2012年第5期47-48,共2页Journal of North Pharmacy

基　　金：科技型中小型企业技术创新基金(立项代码11026214413177);广州市白云区科技攻关项目(2009-SZ-31)

摘　　要：目的:对载体助溶剂的配方进行了系统研究,从而优选出一种最佳载体助溶剂。方法:选择一系列不同载体助溶剂协同超临CO2对迷迭香干叶进行萃取研究,考察不同载体助溶剂对萃取产物理化性状和鼠尾草酸萃取收率的影响。结果:与其他载体助溶剂相比,选择复合载体助溶剂"E6K-10ET",不但能够使得萃取产物的理化性状得到明显改善,而且助溶效果非常显著,鼠尾草酸萃取收率从纯超临界CO2时的25.83%提高到62.14%。结论:复合载体助溶剂"E6K-10ET"即为优选的最佳载体助溶剂。Objective：Study Systematically on formulations of the co-solvent carrier,in order to optimize the best co-solvent carrier.Method：The extraction of rosemary leaf was studied by using supercritical CO2 fluid combined with a series of different co-solvent carriers.Results：The results showed that as a formulated solvent carrier,E6K-10ET,could not only improve greatly the physical-chemical properties of the antioxidant extract of rosemary,but also promote sharply the solubility of carnosic acid during the extraction,which resulted in that the extraction yield of carnosic acid increased up to more than 62.14 % from 25.83 % in the pure supercritical CO2.Conclusion：A formulated cosolvent carrier,E6K-10ET,is the best co-solvent carrier.

关 键 词：载体助溶剂 超临界二氧化碳萃取 迷迭香抗氧化剂 鼠尾草酸 

分 类 号：R284.1[医药卫生—中药学]