尼莫同联合脑蛋白水解物治疗非痴呆型血管性认知障碍的临床观察  

Clinical Observation of Nimotop Combined with Cerebroprotein Hydrolysate Injection in the Treatment of VCIND

作　　者：欧阳方[1] 欧阳存[1] 

机构地区：[1]江汉大学附属医院神经内科,湖北武汉430015

出　　处：《江汉大学学报（自然科学版）》2012年第2期85-88,共4页Journal of Jianghan University：Natural Science Edition

摘　　要：目的:评价尼莫同和脑蛋白水解物注射液治疗非痴呆型血管性认知障碍(VCIND)的疗效。方法:将42例VCIND患者分为3组,各14例,A组口服尼莫同30 mg,tid;B组脑蛋白水解物注射液90 mg加入5%葡萄糖注射液(或0.9%氯化钠注射液)250 mL缓慢静滴qd;C组尼莫同30 mg,tid,联合脑蛋白水解物注射液90 mg加入5%葡萄糖注射液(或0.9%氯化钠注射液)250mL缓慢静滴qd,疗程均为14 d。2周治疗前后MoCA量表中文版及MMSE量表评分的变化,将结果进行统计学处理。结果:2周内,尼莫同联合脑蛋白治疗组治疗后MoCA量表中文版评分较治疗前有明显改善,且较其他组明显,差异有统计学意义(P<0.05)。单药治疗组治疗前后评分无显著改善,差异无统计学意义(P>0.05),而MMSE评分均无明显改善(P>0.05)。结论:按MoCA量表评定:尼莫同联合脑蛋白治疗非痴呆型血管性认知障碍疗效显著,优于单独使用尼莫同及脑蛋白。Objective： Clinical observation of nimotop combined with cerebroprotein hydrolysate injection in the treatment of vascular cognitive impairment no dementia（VCIND） Methods： 42 VCIND cases were divided into three groups,each with 14 cases： Group A taking oral nimotop 30mg,tid;Group B injecting cerebroprotein hydrolysate injection 90mg in 5% glucose injection（or 0.9% sodium chloride injection） 250 mL slow intravenous infusion qd;Group C injecting nimotop 30mg,tid combined with cerebroprotein hydrolysate injection 90 mg in 5% glucose injection（or 0.9% sodium chloride injection） 250 mL slow infusion qd.Duration of treatment was 14 days.Two weeks before and after treatment,the Chinese version of MoCA scale and MMSE changes were taken.The results were analyzed statistically.Results： Within two weeks,the Chinese version of MoCA scale score of the combined treatment group was significantly improved compared with other groups.The difference was statistically significant（P 0.05）.Monotherapy before and after treatment score was no significant improvement.The MMSE scores were not improved（P 0.05）.Conclusion： Rating scale by MoCA： nimotop combined by cerebroprotein hydrolysate injection in treatment of VCIND were significantly superior to nimotop alone and to Cerebroprotein hydrolysate injection.

关 键 词：非痴呆型血管性认知障碍 尼莫同 脑蛋白水解物 MoCA量表中文版 MMSE量表 

分 类 号：R749.105[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]