新型硫代乙酰胺为桥基的噻唑三唑类化合物的合成及抑菌活性  

Synthesis and antibacterial activities of novel thioacetamide derivatives containing triazole and thiazole ring

作　　者：高海燕[1] 卢俊瑞[1] 辛春伟[1] 鲍秀荣[1] 冯钟念[1] 董双双[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津理工大学学报》2012年第2期39-42,53,共5页Journal of Tianjin University of Technology

基　　金：国家自然科学基金(20776114;20976135);天津市高校科技发展基金(2006ZD33;20050712)

摘　　要：本文以具有良好生物活性的1,3,4-噻二唑、1,2,4-三唑为先导物,通过化学修饰合成了4种同时含有1,3,4-噻二唑、1,2,4-三唑、酰胺和硫醚片断的新型目标化合物,并利用1HNMR、IR进行了结构表征.抑菌测定表明:目标化合物对大肠杆菌,白色念珠菌的抑菌率均达84%以上,尤其是对金黄色葡萄球菌的抑菌活性高达90%以上,具有强抑菌活性.In this paper,four novel compounds which simultaneously possess 1,2,4-triazole,1,3,4-thiadiazole,amide,and sulfide fragments were designed and synthesized through chemical modification by using 1,2,4-triazole and 1,3,4-thiadiazole as the lead compounds.The structures have been characterized by 1H NMR and IR.The preliminary bioassay which is more than 85% inhibitory rate against Escherichia coli and Monilia albicans and is over 90% against Staphylococcus aureus at 0.01% mass concentration.Indicates that the target compounds possess a stronger antibacterial activity.

关 键 词：1 2 4-三唑 1 3 4-噻二唑 合成 构效关系 

分 类 号：TQ252[化学工程—有机化工]