度洛西汀联合心理干预治疗躯体形式障碍的对照研究  

Comparative study of duloxetine and psychological intervention in the treatment of somatoform disorders

作　　者：王俊[1] 徐辉霞[1] 孙守英[1] 

机构地区：[1]滨州市人民医院精神卫生中心,滨州256610

出　　处：《中华行为医学与脑科学杂志》2012年第5期424-426,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨度洛西汀联合心理干预治疗躯体形式障碍的临床疗效。方法将67例躯体形式障碍患者采用随机数字表法随机分为研究组（度洛西汀合并心理干预）34例和对照组（单用度洛西汀）33例。应用症状自评量表（SCL-90）、汉密顿焦虑量表（HAMA）及大体评定量表（GAS）进行评定。结果治疗8周后研究组SCL-90躯体化、强迫、抑郁、焦虑、恐怖因子分分别为（1．39±0．45）分，（1．66±0．52）分，（1．83±0．69）分，（1．73±0．66）分，（1．30±0．48）分，较对照组[分别为（1．78±0．61）分，（1．69±0．47）分，（2．39±0．54）分，（2．11±0．49）分，（1．49±0．78）分]低，差异有统计学意义（P〈0．01）；治疗第2周末、第4周末，研究组SCL-90躯体化、抑郁、焦虑、恐怖因子分较对照组低，差异有统计学意义（P〈0．05）；治疗后，研究组HAMA评分（10．20±3．70）分较对照组（13．07±3．20）分明显下降，差异有统计学意义（P〈0．05）；两组显效率分别为85．29％、60．60％，两组痊愈率差异有统计学意义（χ2=4．08，P〈0．05）。结论度洛西汀合并心理干预治疗躯体化障碍较单一用药疗效更为显著，值得推广应用。Objective To observe the clinical efficacy of duloxetine combined with psychological inter- vention in patients with somatoform disorder. Methods 67 patients with somatoform disorder were randomly divided into two groups： study group （34 cases） treated with duloxetine and psychological intervention and control group （33 cases） treated with duloxetine only. And all the 67 patients in the study were assessed by symptom checklisth-90-R （SCL-90） ,hamilton anxiety scale（HAMA） and global assessment scale（GAS）. Results After 8 weeks treatment, the results of SCL-90 showed that the scores of somatization, obsessive-compulsive, depression, anxiety and phobia factors in the study group（ 1.39 ± 0.45 ; 1.66 ± 0.52 ; 1.83 ± 0.69 ; 1.73 ± 0.66 ; 1.30 ± 0.48 ） were notably lower than that in the control group （ 1.78 ± 0.61 ; 1.69 ± 0.47 ; 2.39 ± 0.54 ; 2.11 ± 0.49 ; 1.49 ± 0.78 ）. And there were significant statistical differences （P〈 0.01 ）. At the end of the 2nd and 4th week the, scores of SCL-90 somatization, depression, anxiety and phobia factors were lower in the study group than the control group with statistical significance （P〈0.05）. At the end of 8th week,the HAMA score in the study group（ 10.20 _± 3.70） was significantly decreased than the control group（ 13.07 ± 3.20）, and with statistical significant （P 〈 0.05 ）. The response rate was 85.29% in study group and 60.60% in control group. And there was a statistically singllificant difference in complete remission （ χ2 = 4.08, P 〈 0.05 ） between the two groups. Conclusion The study indicates that the combi±tion of duloxefine and psychological intervention is more effective in treating somatoform disorder than using dnloxetine only. So this combination treatment is worth generalizing and applying.

关 键 词：度洛西汀 心理干预 躯体形式障碍 

分 类 号：R749.7[医药卫生—神经病学与精神病学]