鸦胆子油乳介入治疗膀胱肿瘤的动物实验研究  

Intra-arterial infusion of bruceatin seed oil emulsion for bladder tumor induced by MNU in rats

作　　者：刘红耀[1] 米振国[1] 王东文[1] 李春华[2] 李柄太 刘春[1] 杨晓峰[1] 佟锦[1] 

机构地区：[1]山西医科大学第一医院泌尿外科,太原030001 [2]山西医科大学中心实验室 [3]山西医科大学电镜室

出　　处：《中华泌尿外科杂志》2000年第6期353-355,共3页Chinese Journal of Urology

基　　金：山西省科学基金!资助 (971 0 2 4 )

摘　　要：目的　探讨鸦胆子油乳介入治疗膀胱肿瘤的作用机理。　方法　以N 甲基亚硝基脲(MNU)为诱癌剂 ,特异性诱发大白鼠膀胱肿瘤。以光镜、扫描电镜、透射电镜等观察髂内动脉介入鸦胆子油乳及以明胶微球为栓塞剂治疗膀胱肿瘤的效果。　结果　MNU诱发膀胱肿瘤率 10 0 .0 % ,鸦胆子油介入组发癌率 6 0 .0 % ,介入加栓塞组发癌率 2 6 .6 % ,三组间差别有显著性意义 (P <0 .0 0 5 )。　结论　鸦胆子油乳介入或加栓塞剂对MNU诱发的大白鼠膀胱肿瘤有抗癌作用。Objective To study intra arterial infusion of bruceatin seed oil emulsion in treating bladder tumor in rats induced by N methy N nitrosourea(MNU). Methods Bladder tumors were induced in female Wistar rats by intravesical administration of MNU.Emulsion of seed oil of bruceatin was infused into the internal iliac artery on both sides for the treatment of the bladder tumors.The morphological alterations of the bladder epithelial cells were studied by light microscopy,scanning and transmission electron microscopy. The rats were randomized into the induced tumor group (group A),untreated group (group B) bruceatin treated group (group C) and the bruceatin treated together with embolization group (group D). Results The incidence of bladder tumor in group A was 100.0%,in group C 60.0% and in group D 26.6%.The difference between A and C,D has been significant ( P <0.005). Conclusions Bilateral intra arterial infusion (internal iliac artery) either with or without embolization is effective in treating bladder tumor induced by MNU in rats.

关 键 词：膀胱肿瘤 鸦胆子油乳 介入疗法 实验研究 

分 类 号：R73-36[医药卫生—肿瘤]