P63,CK5/6,TTF1和napins A联合检测在肺鳞癌和肺腺癌鉴别诊断中的价值  

Value of combined assay of p63,CK5/6,TTF1,and napsin A in differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma

作　　者：田华[1] 梅霞[1] 黄文斌[2] 张同海[2] 王劲松[2] 

机构地区：[1]江都市人民医院病理科,江苏江都225200 [2]南京医科大学附属南京第一医院病理科,南京210006

出　　处：《国际病理科学与临床杂志》2012年第2期99-103,共5页Journal of International Pathology and Clinical Medicine

摘　　要：目的:探讨p63,CK5/6,TTF1和napinsA在肺鳞癌和腺癌鉴别诊断中的价值。方法:应用免疫组织化学EnVision法分别检测42例肺鳞癌和42例肺腺癌中p63,细胞角蛋白5/6(cytokeratin 5/6,CK5/6),甲状腺转录因子1(thyroidtranscriptionfactor-1,TTF1)和napinsA的表达,同时分析它们对肺鳞癌和腺癌诊断的敏感性和特异性。结果:p63和CK5/6在肺鳞癌中的阳性表达率分别为100%和97.6%,明显高于TTF1和napsin A(P<0.01)。而TTF1和napsin A在肺腺癌中的阳性表达率分别为97.6%和100%,明显高于p63和CK5/6(P<0.01)。p63或CK5/6检测对肺鳞状细胞癌诊断的敏感性和特异性分别为100%和92.9%,TTF1和napsin A联合检测对肺腺癌诊断的敏感性和特异性分别为97.6%和100%。结论:p63,CK5/6,TTF1和napins A联合检测有助于肺鳞癌和腺癌的鉴别。Objective： To explore the value of p63,cytokeratin 5/6（CK5/6）,thyroid transcription factor-1（TTF1）,and napsin A in the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma.Methods： The immunohistochemical EnVision technique was used to assay the expression of p63,CK5/6,TTF1 and napsin A in 42 patients with lung squamous cell carcinoma and 42 patients with lung adenocarcinoma.The sensitivity and specificity of measurement of p63,CK5/6,TTF1 and napsin A in the diagnosis of lung squamous cell carcinoma and lung adenocarcinoma were also analysed.Results： p63 and CK5/6 were expressed 100% and 97.6%,respectively,of lung squamous cell carcinomas examined,both of which were higher than those in lung adenocarcinoma（P〈0.01）.The incidence of positive expression of TTF1 and napsin A in lung adenocarcinoma were 97.6% and 100%,higher than those in lung squamous cell carcinoma（P〈0.01）.The sensitivity and specificity of p63 and CK5/6 for the diagnosis of lung squamous cell carcinoma were 100% and 92.9%,respectively.The sensitivity and specificity of TTF1 and napsin A for the diagnosis of lung adenocarcinoma were 97.6% and 100%,respectively.Conclusion： The combined assay for p63,CK5/6,TTF1,and napsin A may be helpful for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma.

关 键 词：肺肿瘤 鳞状细胞癌 腺癌 P63 CK5/6 TTF1 NAPSIN A 

分 类 号：R734.2[医药卫生—肿瘤]