胡椒碱的药代动力学研究进展  

Progress in Pharmacokinetics Study of Piperine

作　　者：刘军辉[1] 吴霞[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《中国实验方剂学杂志》2012年第10期304-307,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81073016);北京市教委科技计划面上项目(KM201010025013);北京市教委人才强教计划(PHR201008402;PHR200907113)

摘　　要：对近年来胡椒科植物中的主要有效成分胡椒碱的药代动力学研究方法和内容进行整理和介绍。使用SciFinder Scholar数据库,以piperine和pharmacokinetics为主题词,截止2010年12月21日共检索85篇文献。引用其中相关性较强的27篇文献进行整理分析。从生物样品预处理、检测方法、胡椒碱的体内吸收、分布、代谢及排泄以及对其他药物生物利用度的影响等方面,总结了近年来胡椒碱的药代动力学研究成果。胡椒碱的药代动力学研究方法及其提高其他药物体内吸收的机制的研究较多,而胡椒碱体内代谢与代谢产物研究有待探索。To summarize and introduce the advances on the analytical methods and pharmacokinetics of piperine, which is the major active constituent of the plants from the family Piperaceae. 85 references were found that containing the keywords of both piperine and pharmacokinetics in SciFinder Scholar Database till Tue Dec 21, 2010. In this paper, the pharmacokinetic of piperine was summarized, including biological specimen pretreatment, sample identification and absorption, distribution, metabolism, excretion of piperine in vivo, and its enhancing the bioavailability of drugs. More studies on the pharmacokinetic and mechanism of how piperine enhance the bioavailability of drugs have been reported. The research of metabolic process and metabolin of piperine should be developed.

关 键 词：胡椒碱 胡椒科 药代动力学 

分 类 号：R285[医药卫生—中药学]