早孕期经腹绒毛穿刺125例临床分析  

Clinical analysis of transabdominal chorionic villus sampling in 125 cases with first trimester

作　　者：张秀兰[1] 范佳鸣[2] 沈晓燕[3] 史骁梁[1] 顾秀莉[4] 何琼霞[4] 

机构地区：[1]绍兴市妇幼保健院产科,浙江绍兴312000 [2]绍兴市妇幼保健院影像科,浙江绍兴312000 [3]绍兴市妇幼保健院遗传学实验室,浙江绍兴312000 [4]绍兴市妇幼保健院产前诊断办公室,浙江绍兴312000

出　　处：《中国计划生育和妇产科》2012年第3期52-54,共3页Chinese Journal of Family Planning & Gynecotokology

基　　金：浙江医药卫生科技计划(2010KYB113)

摘　　要：目的开展经腹绒毛取材在早孕期产前诊断中的应用,提前产前诊断的时间窗口。方法早孕期采用经腹绒毛取材125例,其中人工流产组38例,产前诊断87例。结果平均取材孕周(12.12±1.31)周;穿刺成功率第一阶段68.42%,第二阶段97.65%;对过度倾屈的子宫辅助调整子宫位置后穿刺率由88.07%提高到100%;培养成功率为98.17%。未发生穿刺相关的并发症,发现异常核型4例,而终止妊娠;已分娩正常新生儿62例,继续妊娠中21例。结论孕12周左右在超声引导下经腹绒毛取材是一项安全、可行的早孕期产前诊断方法,可前移产前诊断的时间窗口。Objective To advance the time windows of prenantal diagnosis through transabdominal chorionic villus sampling（TA - CVS） utilized. Methods TA - CVS were performed in 125 cases with first trimester including 38 cases in artificial abortion group and 87 cases with first trimester in prenantal diagnosis group. Results The mean sampling time was （ 12. 12 ±1.31 ） weeks of gestation. The success rate was 68.42% during first period and 97. 65% during second period. The success rate of puncture improved from 88.07% to 100. 00% by regulating the excessive leaned and flexed uterus. No complication was found and 4 cases were terminated for abnormal karyotype. Totally 62 cases deliveried normal newborns and 21 cases were in pregnancy. Conclusion TA - CVS under unhrasound- guided in 12 weeks of gestation is a safe and feasible method for prenatal diagnosis in first trimester which can bring the diagnosis time forward.

关 键 词：早孕期 经腹 绒毛取材 产前诊断 

分 类 号：R714.5[医药卫生—妇产科学]