TAC与AC方案在乳腺癌新辅助化疗中的近期疗效观察  

Observation on Short-Term Effects of TAC and AC Scheme on the Neoadjuvant Chemotherapy in Breast Cancer

作　　者：黄利军[1,2] 易平勇[1,2] 刘晰宇[1,2] 周芳[1,2] 欧阳周[1,2] 孙中义[1,2] 贺军桥[1,2] 周征宇[1,2] 邓宏武[1,2] 

机构地区：[1]湖南省肿瘤医院肿瘤内科,湖南长沙410006 [2]湖南省肿瘤医院乳腺外科,湖南长沙410006

出　　处：《肿瘤药学》2012年第2期123-126,共4页Anti-Tumor Pharmacy

摘　　要：目的观察和比较TAC(多西他赛+阿霉素+环磷酰胺)和AC(阿霉素+环磷酰胺)方案在乳腺癌新辅助化疗中的临床疗效。方法 86例Ⅱb-Ⅲa期乳腺癌患者随机分为两组,每组43例,术前分别应用TAC方案或AC方案进行2～4周期的新辅助化疗,治疗结束后观察和比较两组的治疗有效率和不良反应的发生情况。结果 TAC组总治疗有效率为88.4%,而AC组总治疗有效率为68.1%,TAC组总治疗显著有效率高于AC组(P<0.05)。TAC组病理完全缓解率和缓解率分别为32.6%和88.4%,显著高于AC组(分别为14.0%和55.8%)(P<0.05)。两组患者治疗过程中均出现白细胞减少、血小板减少、恶心呕吐、肝功能异常、心电图异常和脱发的不良反应,但各种不良反应的发生率之间无显著性差异(P>0.05)。结论 TAC方案在乳腺癌新辅助化疗中的疗效优于AC方案。Objective To observe and compare the short-term effects of TAC and AC scheme on the neoadjuvant chemotherapy in breast cancer.Methods 86 cases of breast cancer at clinical stage Ⅱb-Ⅲa were randomly divided into two groups,43 cases in each group.Before operation patients were received neoadjuvant chemotherapy with TAC or AC scheme for 2～4 cycles.The total effective rate and incidence rates of adverse effects were compared after treatment.Results The total effective rate in TAC scheme group was 88.4%,which was significantly higher than that in the AC scheme group（68.1%）（P〈0.05）.The complete remission rate and remission rate in TAC scheme group were respectively 32.6% and 88.3%,which were both significantly higher than those in the AC scheme group（respectively 14.0% and 55.8%）（P〈0.05）.Adverse effects such as leucocytopenia,thrombocytopenia,nausea and vomiting,hepatic dysfunction,electrocardiogram abnormalities and alopecia were all observed in both groups,but there was no significant difference of the incidence rates between two groups（P〈0.05）.Conclusion The therapeutic effects of TAC scheme in the treatment of breast cancer were much better than AC scheme.

关 键 词：乳腺癌 新辅助化疗 不良反应 TAC方案 AC方案 

分 类 号：R737.9[医药卫生—肿瘤]