pN0食管鳞癌nm23、E-cadherin表达与淋巴结微转移关系的研究  

Relationship of nm23 and E-cadherin Expression with Lymph Node Micrometastasis of pN0 Esophageal Squamous Cell Carcinoma

作　　者：钟丽[1] 董晖[1] 周铁军[1] 

机构地区：[1]泸州医学院附属医院肿瘤科,四川泸州646000

出　　处：《现代预防医学》2012年第12期3081-3082,共2页Modern Preventive Medicine

摘　　要：目的探讨pN0食管鳞癌nm23、E-cadherin表达与淋巴结微转移的关系。方法采用Evision免疫组化法检测86例pN0食管鳞癌根治术后原发灶nm23、E-cadherin表达,以AE1/AE3为微转移指标检测淋巴结,分析nm23、E-cad-herin表达与淋巴结微转移的关系。结果 86例pN0期食管鳞癌区域淋巴结通过AE1/AE3免疫组化染色,发现31例(36.0%)有淋巴结微转移,并且淋巴结微转移与肿瘤分化程度和浸润深度有密切联系(P﹤0.05);nm23、E-cadherin在pN0期食管鳞癌原发灶表达阳性率分别为65.1%,67.4%,淋巴结微转移与nm23、E-cadherind的表达呈负相关(P﹤0.01)。结论 pN0期食管鳞癌原发灶nm23、E-cadherin表达缺失是淋巴结微转移的高危因素,两者联合检测有望成为评估微转移风险有用指标。OBJECTIVE To investigate the correlation of non-metastasis 23 （nm23） and epithelial cadherin （E-cadherin） expression with lymph node micrometastasis in pN0 esophageal squamous cell carcinoma. METHODS Immunohistochemistry was used to detect nm23 and E-cadherin in primary cancer tissue and AE1 / AE3 in lymph node. RESULTS Lymph node micrometastasis was found in 31 （36.0%） patients. It was closely correlated to differentiation degree, invasion depth, negative expression of nm23 and E-cadherin （P﹤0.05）. CONCLUSION The examination of nm23 and E-cadherin expression in primary tumors may be useful for predicting lymph node micrometastasis.

关 键 词：NM23 E-CADHERIN 淋巴结微转移 食管鳞癌 

分 类 号：R735.1[医药卫生—肿瘤]