老年大鼠耳蜗螺旋神经节Caspase-3、Calretinin的表达  

Expression of Caspase-3,Calretinin in spiral ganglion of aged rats

作　　者：王永生[1] 董雪蕾[2] 

机构地区：[1]深圳市第三人民医院耳鼻咽喉科,广东深圳518112 [2]郑州大学第三附属医院耳鼻咽喉科,河南郑州450052

出　　处：《中国现代医生》2012年第14期13-14,共2页China Modern Doctor

摘　　要：目的探讨老年性聋的发病机制。方法建立D-半乳糖衰老大鼠模型,获取老年大鼠耳蜗标本并以正常青年大鼠作对照,用免疫组化SP法检测老年大鼠和青年大鼠耳蜗螺旋神经节Caspase-3,Calretinin的表达。结果老年大鼠耳蜗螺旋神经节Caspase-3,Calretinin的积分光密度明显高于对照组(P<0.05)。结论老年大鼠耳蜗螺旋神经节Caspase-3、Calretinin含量升高。Objective To explore injury cochlea mechanism of presbycusis. Methods Establishment of D-galactose aging rats model to obtain the cochlear specimens of aged rats. As a control in normal young rats, using immunohistochemical SP staining methods detected the expression of Caspase-3, Calretinin in the cochlear spiral ganglion of aged rats and young rats. Results The integral optical density of Caspase-3, Calretinin in the spiral ganglion of aged rats was significantly higher than the control group（P 〈 0.05）. Conclusion The content of Caspase-3, Calretinin is increased in the spiral ganglion of aged rats.

关 键 词：老年性聋 耳蜗 螺旋神经节 CASPASE-3 CALRETININ 

分 类 号：R74[医药卫生—神经病学与精神病学] R76[医药卫生—临床医学]