老年脑梗死高血压患者血Hcy、Cystatin C与动态血压参数及颈动脉内膜中层厚度的相关性研究  

Association between Hcy,Cystatin C,ABPM and IMI in cerebral infarction patients with hypertension

作　　者：李美艺[1] 张颜波[1] 刘莉莉[1] 吴月鹏[1] 牛敬忠[1] 

机构地区：[1]泰山医学院附属医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2012年第1期7-9,共3页Journal of Taishan Medical College

基　　金：泰安市科技发展计划资助(20083043)

摘　　要：目的探讨老年脑梗死高血压患者血Hcy、Cystatin C与动态血压各参数及颈动脉内膜中层厚度(IMI)的相关性。方法测定单纯高血压(B)、单纯脑梗死(C)及高血压脑梗死患者(D)与正常老年人(A)血Hcy、Cystatin C、IMI及动态血压值,比较组间差异,分析高血压脑梗死患者各指标间的相关性。结果脑梗死患者Hcy较无脑梗死者升高。高血压患者Cystatin C较血压正常者高,单纯脑梗死患者较正常老年人及高血压患者Cystatin C降低。单纯脑梗死和高血压患者IMI较正常老年人增厚,高血压脑梗死患者增厚更明显。单纯脑梗死患者平均收缩压(SBP)、平均舒张压(DBP)分别低于和高于正常老年人;高血压脑梗死患者SBP、DBP及PP均高于单纯高血压患者。高血压脑梗死组Hcy和Cystatin C与SBP正相关。结论高Hcy血症及IMI增厚是脑梗死危险因素;低Cystatin C血症,低SBP,高DBP是血压正常脑梗死危险因素;高SBP、DBP及PP是高血压脑梗死危险因素,其Hcy和Cystatin C与SBP水平有相关性。Objective： To evaluate the association between serum homocysteine （Hcy）, Cystatin C, ABPM and IMI in cerebral infarction （CI） patients with hypertension. Methods： 220 old CI patients with hypertension were included. The levels of Hey, Cystatin C, ABPM and IMI were recorded and compared with hypertension, CI patients and normal aged people. The relationship between Hcy, Cystatin C, ABPM and IMI of CI patients with hypertension was analyzed. Results ： All the CI patients had a higher serum Hcy level than the non - CI. All hypertensions had a higher serum Cystatin C level than the people with normal blood pressure, but CI patients without hypertension had a lower Cystatin C level than others. Compared with normal aged people, IMI of hypertension - only and CI - only patients were thicker, and the patients with hypertension and CI had the thickest IMI of all. CI patients without hypertension had a lower SBP and a higher DBP com- pared with normal aged people; Hypertension with CI had higher SBP, DBP and PP compared with the hypertension only. Both Hcy and Cystatin C had positive correlation with SBP in CI patients with hypertension. Conclusion： Increased IMI and plasma Hcy was significantly associated with increased CI resistance in all patients. Decrease of serum Cystatin C, lower SBP and higher DBP were risk factors of CI in normal blood pressure group. Higher SBP, DBP and PP increased the risk of CI in hypertension. Advancing of Hcy and Cystatin C may be induced by a high SBP in CI patients with hypertension.

关 键 词：老年脑梗死高血压 Hcy CYSTATIN C 动态血压 颈动脉内膜中层厚度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]