喉癌手术前后血浆前列腺素E_2水平变化及临床意义  

Clinical significance of plasma PGE_2 levels in pre and post operative patients with laryngeal carcinoma

作　　者：李守珍[1] 刘辉[1] 徐晓丽 

机构地区：[1]解放军第153中心医院耳鼻咽喉科,郑州450042 [2]河南武警总队医院眼科

出　　处：《临床耳鼻咽喉科杂志》2000年第3期106-107,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨喉癌患者血浆前列腺素 E2 (PGE2 )水平的临床意义。方法 :应用放射免疫分析法测定 35例喉癌患者血浆 PGE2 水平。结果 :喉癌患者血浆 PGE2 水平显著高于正常对照组 (P <0 .0 5 ) ,但与喉癌的临床分期无关 (P >0 .0 5 )。喉癌患者血浆 PGE2 水平术后较术前显著下降 (P <0 .0 5 ) ,但术后复发者比未复发者的血浆PGE2 水平明显增高 (P<0 .0 1)。结论 :测定患者血浆中 PGE2 含量 。Objective:To study the clinical significance of PGE 2 Levels in patients with laryngeal carcinoma.Method:Radioimmunoassay was used to evaluate plasma PGE 2 levels in 35 patients with laryngeal carcinoma.Result:The plasma PGE 2 levels in patients with laryngeal carcinoma were significant higher than that of normal subjects (P< 0.05 ),but there was no correlation with the stage of laryngeal carcinoma (P> 0.05 ).The plasma PGE 2 levels of postoperative patients with laryngeal carcinoma were significant lower than that of preoperative patients (P< 0.05 ).After operation,the plasma PGE 2 levels of recurrent patients were significant higher than that in patients with no recurrence (P< 0.01 ). Conclusion:The determination of PGE 2 levels in patient plasma may help the diagnosis and prognostic judgment of laryngeal carcinoma.

关 键 词：喉肿瘤 前列腺素E2 鳞状细胞癌 肿瘤 复发 

分 类 号：R739.65[医药卫生—肿瘤]