MMP-9对大鼠脑出血后DCX表达的影响  

Role of MMP- 9 in neurogenesis after cerebral hemorrhage in rats

作　　者：杨晓波[1] 沈卫红[1] 任伟民[2] 祖恒兵[1] 

机构地区：[1]上海复旦大学附属金山医院神经内科,201508 [2]上海复旦大学附属金山医院病理科,201508

出　　处：《神经疾病与精神卫生》2012年第2期172-174,共3页Journal of Neuroscience and Mental Health

摘　　要：目的探讨脑出血后MMP-9对大鼠神经修复的影响。方法采用立体定向技术制作大鼠脑出血模型，用免疫组化方法测定脑出血后血肿周围及SVZ区DCX及MMp-9表达。结果与对照组（MMP-9：116．865±5．126；DCX：121．34±2．76）相比，在第14天时脑出血组MMP9、DCX表达最强，灰度值最小（MMP-9：102．801±2．422，P〈0．05；DCX：110．58±2．29，P〈0．05），干预组较脑出血组表达弱，灰度值增大（MMP-9：109．31±2．13，P〈0．05；DCX：ii5．50±3．12，P〈0．05）。结论脑出血恢复期MMP-9可能是促进神经再生因子，多西环素能通过调节MMP-9的表达与活性影响神经再生。Objective To study the effect of MMP-9 in neurogenesis after cerebral hemorrhage. Methods We employed the stereotactic technique to make models of the cerebral hemorrhage of mice . The level of MMP- 9 and the situation of DCX masculine-newborn cells with immuno-histochemistry after ICH were detected. Results Compared with the control group,the expression of MMP- 9 and DCX was highest.and the average gray value was lowest in the model group in day 14. The expression of MMP - 9 and DCX in the intervention group was lower than that of the model group. Conclusions MMP- 9 may be the factor to promote neurogenesis after cerebral hemorrhage and doxycycling can affect the neurogenesis by adjusting the expression and the activity of MMP-9. [

关 键 词：脑出血 神经再生 多西环素 MMP-9 DCX 

分 类 号：R743.3[医药卫生—神经病学与精神病学]