针刺联合抗抑郁药治疗抑郁症44例临床观察  

Clinical Observation of Acupuncture Combined with Antidepressants for 44 Cases of Depression

作　　者：郑美[1] 林燕红[1] 张建斌[1] 王玲玲[1] 乔慧芬 

机构地区：[1]南京中医药大学第二临床医学院 [2]南京市脑科医院医学心理科

出　　处：《中医杂志》2012年第11期927-929,932,共4页Journal of Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划项目(2006BAI12B05)

摘　　要：目的观察针刺介入治疗抑郁症的临床疗效及不良反应。方法将98例抑郁症患者随机分为药物对照组54例、针刺介入组44例,两组患者均酌情选用1种选择性5-羟色胺再摄取抑制剂(SSRI)类抗抑郁药口服,连续治疗6周;针刺介入组在此基础上针刺神庭、百会、风池、大椎、神道、至阳并随症加减治疗。记录两组在治疗前和治疗第1、2、4、6周及随访时汉密尔顿抑郁量表(HAMD)总评分,以及治疗第1、2、4、6周时副反应量表(SERS)评分,并根据HAMD减分率统计疗效。结果药物对照组愈显率为61.11%、总有效率为85.19%,针刺介入组分别为90.90%、100%,两组愈显率比较差异有统计学意义(P<0.01),总有效率比较差异有统计学意义(P<0.05)。针刺介入组HAMD总分在治疗第1、2、4、6周时均明显低于药物对照组(P<0.05或P<0.01);针刺介入组SERS评分在治疗第2、4、6周时均明显低于药物对照组(P<0.01)。结论针刺介入治疗抑郁症临床疗效优于单用药物治疗,主要表现为起效快且能明显减轻药物不良反应等。Objective To observe the therapeutic effect and adverse reactions of acupuncture intervention for depression. Methods Ninety eight depression patients were randomized into control group of 54 cases and intervention group of 44 cases. Both groups were given one kind of selective 5-HT reuptake inhibitor （SSRI） antidepressants orally. The treatment course las- ted for 6 weeks. The intervention group was added with acupuncture on Shenting （GV24）, Baihui （GV20）, Fengchi （GB20）, Dazhui （GV14）, Shendao （GVll） and Zhiyang （GVg）. The total scores of Hamilton Depression Rating Scale for Depression （HAMD） were recorded before the treatment and in the 1st, 2nd, 4th and 6th week of the treatment and after 1 month of follow-up. The scores of Side Effect Rating Scale （SERS） were recorded before the treatment and in the 2nd, 4th and 6th week of the treatment. The therapeutic effect was analyzed according to the reduced rate of HAMD. Results The excellence rate and total effective rate of the control group was 61.11% and 85.19%, which was inferior to 90.90% and 100% of the intervention group respectively （P〈0.01 or P〈0.05）. The total scores of HAMD in the intervention group were significantly lower than those in the control group in the 1st, 2nd, 4th and 6th week of the treatment （P〈0.05 or P〈0. 01）. The scores of SERS in the intervention group were significantly lower than those in the control group in the 2nd, 4th and 6th week of the treatment （P 〈0.01）. Conclusion The intervention with acupuncture is more effective than the single drug therapy for depression with a rapid onset and lower adverse reactions.

关 键 词：抑郁症 针刺 汉密尔顿抑郁量表 副反应量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R246.6[医药卫生—临床医学]