血清特应性变应原及总IgE抗体与抽动障碍发病的关系  

Relationship between Tic Disorder and Levels of Total Immunoglobulin E and Serum Specific Allergen

作　　者：鞠俊[1] 李尔珍[2] 马秀清[3] 李晓燕[1] 张玮娜[1] 邹丽萍[1] 

机构地区：[1]中国人民解放军总医院儿童医学中心,北京100853 [2]首都儿科研究所附属儿童医院神经科,北京100020 [3]中国人民解放军总医院呼吸科实验室,北京100853

出　　处：《实用儿科临床杂志》2012年第9期658-660,共3页Journal of Applied Clinical Pediatrics

基　　金：首都临床特色应用研究(D101100050010040)

摘　　要：目的抽动障碍(TD)病因尚不明确,通过对TD患儿血清总IgE及特应性变应原IgE进行检测,探讨TD与过敏反应的关系。方法本研究对62例TD患儿进行血清总IgE抗体和特应性变应原检测。收集TD患儿静脉血3 mL,采用欧蒙医学实验诊断股份公司的特应性变应原中国组合3检测试剂盒(欧蒙印迹法)进行总IgE抗体、吸入性和食物变应原特异性IgE抗体(sIgE)检测。结果本研究中TD患儿90.32%以眨眼、挤眼等眼部表现和鼻咽部抽动症状起病。患TD儿童血清总IgE抗体阳性者52例,阳性率为83.87%。血清特异性变应原sIgE检测阳性44例,阳性率为70.97%。吸入性变应原sIgE阳性率高于食物变应原,TD患儿常见变应原有屋尘、树组合(榆树/梧桐树/柳树/杨树/柏树)、尘螨组合(屋尘螨/粉尘螨)、牛奶/巧克力混合、海鲜组合(蟹,扇贝,虾,蛤)。总IgE等级分布与病程长短无关。结论血清特应性变应原及高总IgE抗体可能是引起TD的一个重要原因。Objective To investigate the relationship between tic disorders（TD） and levels of total immunoglobulin E（IgE） and serum allergen- specific IgE（sIgE）. Methods Sixty -two children with TD were implemented laboratory check about the total immunoglobulin E （IgE） and allergen - sIgE in serum. Three mL vein blood were collected from the TD patients. The total IgE as well as inhalant allergen - sIgE, food allergen -sIgE in serum were measured by EUROLINE Atopy（ China3 ）（IgE） from EUROIMMUN Medizinische Labordiagnostika AG. Results The majority of cases （90.32%） had symptoms of blinking tics alas pharynx nasalls tics from the onset. Fifty - two cases had positive total IgE, the positive rate was 83.87% ; 44 cases had positive allergen - sIgE, the positive rate was 70.97%. The positive rate of in- halant allergen -sIgE was higher than that of food allergen -sIgE. House dust, wood combination （willow, poplar, elm）, dust mites （derma- tophagoides pteronyssinus, dermatophagoides culinae）, milk - chocolate combination, and mixed seafood （ crabs, scallop, shrimp, and clam） were the common allergens. The rank distributions of the total IgE had nothing to do with course of disease. Conclusion Total IgE and serum allergen - sIgE may be important factors evoking the TD.

关 键 词：抽动障碍 变应原检测 病因 

分 类 号：R749.94[医药卫生—神经病学与精神病学]