TACE联合三维适形放疗治疗肝癌合并门静脉癌栓的疗效观察  

Clinical investigation on the efficacy of TACE combined with three-dimensional conformal radiotherapy for hepatocellular carcinoma with portal vein tumor thrombus

作　　者：刘永国[1] 

机构地区：[1]重庆市急救医疗中心肝胆外科,重庆400014

出　　处：《四川医学》2012年第5期790-792,共3页Sichuan Medical Journal

摘　　要：目的探讨肝动脉化疗栓塞术(TACE)联合三维适形放疗技术(3DCRT)治疗原发性肝癌(PHC)合并门静脉癌栓(PVTT)的临床疗效和安全性。方法 60例经病理组织学确诊的PHC伴PVTT患者分为治疗组和对照组。治疗组采用TACE联合3DCRT治疗,对照组单纯采用TACE治疗。疗程结束后评价近期疗效、观察不良反应,随访1年评价客观疗效和生存率。结果治疗组近期疗效有效率为80.0%,高于对照组(43.3%),相比较差异有统计学意义,P<0.05;治疗组患者随访期内有18例死亡,对照组患者随访期内有24例死亡,治疗组中位疾病进展时间、1年生存率显著高于对照组,相比较差异有统计学意义,P<0.05。两组患者对毒性反应均可耐受。结论 TACE联合3DCRT治疗PHC合并PVTT患者临床疗效肯定,不良反应小,值得临床推广应用。Objective To evaluate the clinical efficacy and safety of hepatic arterial chemoembolization（TACE） combined with three-dimensional conformal radiotherapy（3DCRT） treatment on hepatocellular carcinoma（PHC） patients with and portal vein tumor thrombus（PVTT）.Methods 60 cases of histologically confirmed patients were divided into two groups： treatment and control groups.The treatment group were treated with TACE combined with 3DCRT treatment,control group were treated with TACE treatment only.After treatment,the short-term effect and toxicity were evaluated,and the long-term effect and survival rate were determined after 1-year follow-up.Results the effective rate of short-term effect of the treatment group（80.0%） was higher than that of the control group（43.3%）,statistical results suggested the difference reached statistical significance,P〈0.05.During the follow-up period,18 cases from the treatment group while 24 patients from the control group died.The median time of disease progression and 1-year survival rate in treatment group were significantly higher than control group,P〈0.05.The two groups all exibited tolerance to toxicity.Conclusion With the advantage of better effect,smaller toxicity,the strategy of TACE combined with the 3DCRT on PHC patients with PVTT worth clinical application.

关 键 词：门静脉癌栓 原发性肝癌 肝动脉化疗栓塞术 三维适形放疗技术 

分 类 号：R735.7[医药卫生—肿瘤]