甲硝哒唑肛门栓防治胃肠道穿孔性腹膜炎术后切口感染及血浓监测  

Metronidazole suppositories for prevention of postoperative infection of gastrintestinal perforative peritonitis and drug plasma monitoring

作　　者：屈建 宋宇红 田莉 徐荣楠 姚恒德 滕安宝 

机构地区：[1]安徽省立医院药剂科临床药学室 [2]安徽省立医院普外科

出　　处：《中国药学杂志》1990年第10期592-594,共3页Chinese Pharmaceutical Journal

摘　　要：术前单次应用甲硝哒唑肛门栓(1g)可有效地降低胃肠道穿孔性腹膜炎及急性阑尾炎术后切口感染率。我院对527例胃肠道穿孔性腹膜炎患者术前使用肛栓,使切口感染率由27.5%降至8.5%(P<0.05)。测得9名健康志愿者(男4,女5)及5名患者(男3,女2)的血清甲硝哒唑浓度,C_(max)分别为:男性志愿者15.62mg/L,女性志愿者11.88mg/L,患者10.53mg/L,表明体内药物已达到有效浓度,其它药动学参数(Ka、K、t_(max)、t_?)与文献接近,从而为临床单次应用甲硝哒唑肛门栓提供了实验依据。Metronidazole rectal suppositories (1 g) are usedsingly before operation for gastro intestinal perfora-tive periotonitis and acute appendicitis to lowerinfection rate from 27.5% down to 8.5% (P<0.05).The serum concentrations of metronidazole of 9healthy volunteers (male 4, female 5) and 5 patients(male 3, female 2) were determined. The maximal serum concentration reached the effective concen-tration (male volunteers 15.62mg/L; female 11.83mg/L; patients 10.53mg/L).

关 键 词：甲硝哒唑 肛门栓 血药浓度 监测 

分 类 号：R914.1[医药卫生—药物化学]