凝血酶激活纤溶抑制物基因启动子区-438A/G多态性与脑梗死的关系  

Relationship between Promoter Polymorphism-438 A/G of Thrombin-activatable Fibrinolysis Inhibitor Gene and Cerebral Infarction

作　　者：陈煜森[1] 曾志良[1,2] 林智君[1] 冼文川[1] 钟望涛[1] 赵斌[1] 许志恩[1] 

机构地区：[1]广东医学院附属医院神经内科,广东湛江市524001 [2]东莞市太平人民医院,广东东莞市523900

出　　处：《中国康复理论与实践》2012年第5期406-408,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：教育部留学回国人员科研启动基金(教外司留[2005]546号)

摘　　要：目的分析中国汉族人群凝血酶激活纤溶抑制物基因启动子区-438A/G(TAFI-438A/G)多态性与动脉粥样硬化性脑梗死(ACI)发病的关系。方法 225例ACI患者(病例组)和184例健康体检者(对照组)采用聚合酶链反应-限制性内切酶片段长度多态性分析方法(PCR-RFLP)检测TAFI-438A/G多态性。结果 TAFI-438A/G基因型及等位基因频率在病例组与对照组之间无显著性差异。性别分层后,男性脑梗死组A等位基因频率为28.6%,高于对照组20.6%(P=0.039);AA基因型为9.0%,高于对照组1.9%(P=0.019);在女性中无显著性差异。结论 TAFI-438A/G可能与男性脑梗死的发病有关,AA基因型可能增加男性脑梗死患病风险。Objective To research the relationship between promoter polymorphism-438 A/G of thrombin-activatable fibrinolysis inhibi- tor gene （TAFI-438 A/G） and atherosclerotic cerebral infarction （ACI） in Chinese Han population. Methods TAFI-438A/G genotypes and their allele frequencies were identified with the polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） in 225 ACI patients and 184 healthy controls. Results There was no significant difference of TAFI-438A/G polymorphism between ACI group and control group. Stratified by gender, in males, the incidence of A allele was 28.6% in ACI group, and 20.6% in control （P=0.039）; of the AA genotype was 9.0% in ACI group, and 1.9% in control （P=0.019）. But no significant difference was found in females. Conclusion TAFI-438A/G polymorphism is associated with the risk of ACI in males, that AA genotype may increase the risk of ACl.

关 键 词：凝血酶激活纤溶抑制物 启动子 基因多态性 动脉粥样硬化 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]