MUC1在Ⅰ型子宫内膜癌组织中的表达模式及临床意义  

Patterns of MUC1 expression in endometrial carcinomas Type Ⅰ and its significance

作　　者：赵时梅[1] 罗宇[1] 任传伟[1] 史琳[1] 

机构地区：[1]柳州医学高等专科学校病理教研室,广西柳州545006

出　　处：《山东医药》2012年第19期10-12,共3页Shandong Medical Journal

基　　金：广西壮族自治区教育厅科研项目(200911MS285)

摘　　要：目的探讨跨膜型黏蛋白1(MUC1)在Ⅰ型子宫内膜癌发生、发展中的作用及其临床意义。方法选择手术切除的增生期子宫内膜组织30份(增生组)、单纯性增生子宫内膜36份(单纯组)、不典型增生内膜组织50份(不典型组)及Ⅰ型子宫内膜癌55份(内膜癌组),采用免疫组化法检测各组MUC1蛋白的表达模式,分析MUC1表达与子宫内膜癌临床病理参数的相关性。结果 MUC1蛋白在增生组和单纯组主要表现为上皮细胞膜顶点和腺体腔源面表达(A模式),在不典型组和内膜癌组表现为整个细胞膜表面或细胞质表达(A/C模式),P均<0.01;内膜癌中MUC1蛋白表达与年龄变化有一定关系(P=0.044),但与组织学分级无关(P=0.678)。结论 MUC1蛋白参与了Ⅰ型子宫内膜癌的发生、发展过程,其在内膜上皮细胞细胞膜表面或细胞质中表达模式可作为诊断子宫内膜癌的参考指标。Objective To investigate the patterns of MUC1 expression and its significance in the endometrial carcinoma type I Methods The pattems of MUC1 protein expression in endometrial carcinomas type I （ n = 55 ）, endometrial atypical hyperplasia （ n = 50 ）, endometrial hyperplasia （ n = 36 ） and normal proliferative endometrium （ n = 30 ） were examined by immunohistochemistry （Envision method）, the correlation between the MUC1 expression and clinicopathologic parameters were analyzed. Results MUC1 immunostain in the endometrial hyperplasia and the normal proliferative endo- metrium was showed ＂pure apical＂ mostly （type A）, but in the endometrial atypical hyperplasia and the endometrial carcinomas type I , it was displayed ＂combined apical/cytoplasmic＂ mostly （type A/C）. The difference was significant （all P 〈 0. 01 ） ; The patterns of MUC1 protein expression in endometrial carcinomas was associated with the age （ P = 0.044 ）, but was not related to the histological grade （ P = 0. 678 ）. Conclusions The MUC1 protein involves in the development of endometrial carcinomas type I , its expression pattern ＂combined apical/cytoplasmic＂ may take as a diagnostic indicator of the endometrial carcinomas.

关 键 词：子宫肿瘤 腺癌 黏蛋白1 

分 类 号：R737.33[医药卫生—肿瘤]