术中植入5-Fu缓释剂对原发性肝癌术后早期复发的影响  

Influence of implanting slow-released 5-flourouracil during hepatectomy on early recurrence of hepatocellular carcinoma

作　　者：陈元元[1] 梁中骁[1] 潘金飞[1] 

机构地区：[1]广西壮族自治区人民医院,南宁530021

出　　处：《山东医药》2012年第19期61-63,共3页Shandong Medical Journal

基　　金：广西医疗卫生重点科研课题(200812)

摘　　要：目的观察在肝癌根治术中植入5-氟尿嘧啶(5-Fu)缓释剂对原发性肝癌早期复发的影响。方法将100例原发性肝癌行肝癌根治术患者随机分为两组各50例。观察组于术中完整切除肿瘤后于残肝断面及大网膜分别植入5-Fu缓释剂,对照组不植入。比较两组术前1 d及术后1个月血清甲胎蛋白(AFP)水平及术后1年复发率。结果两组术后AFP水平明显均低于术前,观察组明显低于对照组,P均<0.01;观察组1年复发率明显低于对照组,P<0.05。结论肝癌根治术中局部植入5-Fu缓释剂可明显降低血清AFP水平,减少肝癌早期复发率。Objective To investigate the effect of implanting slow-released 5-Fu during operation on early recurrence of patients with hepatocellular carcinoma. Methods One hundred patients with hepatocellular carcinoma undergoing hepa- tectomy were divided into two groups randomly. The observation group were implanted with slow-released 5-Fu on the liver sections and epiploon when the carcinomas were completely resected, while the patients in control group accepted hepatec- tomy alone. The serum level of alpha fetoprotein （AFP） 1 day before, 1 month after the operation and the 1-year recur- rence rate were compared between two groups. Results The serum levels of AFP after the operation were significantly low- er than that before the operation in both groups, and which in observation group was significantly lower than that in control group, both P 〈0.01. The 1-year recurrence rate was significant lower in observation group than that in control group, P 〈 0.05. Conclusions Implanting slow-released 5-flourouracil during hepatectomy can decrease the serum level of AFP and the early recurrence rate of hepatocellular carcinoma.

关 键 词：5-氟尿嘧啶 缓释剂 肝肿瘤 肝癌 间质化疗 复发率 

分 类 号：R735.7[医药卫生—肿瘤]