肺癌血型物质A、B、H抗原免疫组织化学研究——肺癌分子病理学研究之三  

IMMUNOCYTOCHEMICAL STUDY ON HUMAN BLOOD GROUP ANTIGEN A,B AND H IN PULMONARY CARCINOMA

作　　者：陈琇文 贾心善[2] 裴惠敏[2] 

机构地区：[1]南京铁道医学院 [2]中国医科大学病理解剖学教研室

出　　处：《中国医科大学学报》1990年第3期169-172,共4页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：采用免疫组织化学方法,对肺癌组织中的血型物质A.B.H抗原进行检查,其结果表明:绝大多数的肺癌组织血型物质减少或消失。在B型和O型患者癌组织中可以出现反常A抗原(incompatible Aantigen)。上述变化的机理可能是:(1)糖链合成不全,前驱物质的蓄积;(2)新的糖链合成。细胞在癌变过程中,细胞膜上糖脂质、糖蛋白的糖链发生很大的变化,这一免疫学去分化的重要标志,可作为一个新的肿瘤标记应用于癌研究。Immunocytochemical methods were used to detect human blood group antigenA, B and H in the tissues of pulmonary carcinoma. The results indicated thatthese blood group antigens decreased or disappeared in most of the specimens.However, incompatible A antigen appeared in some tissue specimens taken fromthe patients whose blood group was B or O. These interesting phenomena maybe explained as incomplete synthesis of carbohydrate chains and accumulation oftheir precursors, or synthesis of new carbohydrate chains, since the carbohydratechains of glycolipids and glycoproteins on cell membrane are altered dramaticallyin the process of cell carcinogenesis. The alterations of immunological dediffe-rentiation of human cells should be regarded as new tumor markers for cancerresearch.

关 键 词：肺癌 血型抗原 免疫组织化学 

分 类 号：R734.202[医药卫生—肿瘤]