Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases  

作　　者：Guo Qiang Hu Xiao Kui Wu Guo Qiang Wang Nan Nan Duan Xiao Yi Wen Tie Yao Cao Yin Jun Wang Wei Song Qiang Xie Wen Long Huang 

机构地区：[1]Institute of Chemistry&Biology,Henan University,Kaifeng 475001,China [2]China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2012年第5期515-517,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos20872028 and 21072045)

摘　　要：To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.

关 键 词：FLUOROQUINOLONE Schiff base Antitumor evaluation 

分 类 号：Q78[生物学—分子生物学] O626[理学—有机化学]