家族性与散发性精神分裂症中枢5-羟色胺与多巴胺相互作用比较研究  

A comparative study on difference in interaction of central serotonin and dopamine between familial and sporadic schizophrenia.

作　　者：金卫东[1] 臧德馨[2] 施建安[1] 赵汉清[1] 刘桂永[1] 崔庶[1] 

机构地区：[1]江苏常州解放军102医院,213000 [2]湖北医科大学附一院

出　　处：《四川精神卫生》2000年第1期4-5,共2页Sichuan Mental Health

摘　　要：目的　比较家族性与散发性精神分裂症中枢 5—HT与DA相互作用的差异。方法　应用高效液相色谱(HPLC)对 2 0例家族性和 47例散发性精神分裂症的脑脊液中 5—HT、5—HIAA、DA、HVA进行测试 ,并以比值作为相互作用指标。结果　家族性精神分裂症的 5—HIAA/HVA比值显著高于散发性 (t =2 0 86,P =0 0 41)。结论　两类型精神分裂症存在着Objective To study the difference in interaction of serotonin(5-HT) and dopamine (DA) between familial and sporadic schizophrenia.Methods The levels of 5-HT,5-HTAA,DA and HVA in CSF of 20 familial and 47 sporadic schizophrenic patients were detemined by high pressure liguid chromatography.Results The ratio of 5-HTAA/HVA of familial schizophrenia was significantly higher than that of sporadic schizophrenia.Conclusion The familial schizophrenia and sporadic schizophrenia were different in interaction of central 5-HT and DA.

关 键 词：精神分裂症 家族史 5-羟色胺 多巴胺 治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]