上皮向间质转化在消化道肿瘤中的研究进展  

Epithelial-mesenchymal transition in digestive system tumors

作　　者：许春红[1] 邹晓平[1] 

机构地区：[1]南京医科大学附属鼓楼临床医学院消化内科,210008

出　　处：《国际肿瘤学杂志》2012年第5期380-383,共4页Journal of International Oncology

基　　金：基金项目：国家自然科学基金资助项目（81071816）

摘　　要：近年研究发现，肿瘤细胞发生上皮向间质转化（EMT）摆脱细胞与细胞间连接而发生转移侵袭，已成为上皮细胞癌转移侵袭以及化疗耐药的一个重要途径。Snail家族成员，尤其是Snail被认为是肿瘤EMT发生的重要调节因子，它可以通过竞争性抑制E一钙黏蛋白基因的表达，引起上皮细胞向间质细胞表型的转变，最终引起EMT。多项研究显示，在消化系统肿瘤中普遍存在EMT现象，并与这些肿瘤的侵袭转移及化疗耐药密切相关。Recent studies show that tumor cells get rid of the connections between cells, and induce tumor invasion and metastasis through epithelial-mesenchymal transition （EMT）. EMT becomes an important way to invasion, metastasis and chemotherapy resistance of epithelial cell carcinoma which accounting for more than 90% of malignant carcinomas. Members of Snail family, especially Snail is regarded as important adjust- ment factor of EMT, which induce the transformation from epithelial cell to mesenchymal phenotype through competitive inhibition E-calcium protein gene expression. Many researches show that EMT exists widely in digestive system tumors, which is closly related to the invasion, metastasis and chemotherapy resistance of digestive system tumors.

关 键 词：上皮向间充质转化 消化系统肿瘤 糖蛋白类 

分 类 号：R735[医药卫生—肿瘤]